null

SMILES: ONC(=O)C1(CCOCC1)S(=O)(=O)c1ccc(Oc2cccc(Cl)c2)cc1

InChI Key: InChIKey=KOPIIXVBCHXDHO-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50348675   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50348675 (CHEMBL1801045) Show SMILES ONC(=O)C1(CCOCC1)S(=O)(=O)c1ccc(Oc2cccc(Cl)c2)cc1 Show InChI InChI=1S/C18H18ClNO6S/c19-13-2-1-3-15(12-13)26-14-4-6-16(7-5-14)27(23,24)18(17(21)20-22)8-10-25-11-9-18/h1-7,12,22H,8-11H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human MMP9 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay				J Med Chem 53: 6653-80 (2010) Article DOI: 10.1021/jm100669j BindingDB Entry DOI: 10.7270/Q2KH0NQB
					More data for this Ligand-Target Pair
Matrix metalloproteinase-14 (Homo sapiens (Human))	BDBM50348675 (CHEMBL1801045) Show SMILES ONC(=O)C1(CCOCC1)S(=O)(=O)c1ccc(Oc2cccc(Cl)c2)cc1 Show InChI InChI=1S/C18H18ClNO6S/c19-13-2-1-3-15(12-13)26-14-4-6-16(7-5-14)27(23,24)18(17(21)20-22)8-10-25-11-9-18/h1-7,12,22H,8-11H2,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human MMP14 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay				J Med Chem 53: 6653-80 (2010) Article DOI: 10.1021/jm100669j BindingDB Entry DOI: 10.7270/Q2KH0NQB
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50348675 (CHEMBL1801045) Show SMILES ONC(=O)C1(CCOCC1)S(=O)(=O)c1ccc(Oc2cccc(Cl)c2)cc1 Show InChI InChI=1S/C18H18ClNO6S/c19-13-2-1-3-15(12-13)26-14-4-6-16(7-5-14)27(23,24)18(17(21)20-22)8-10-25-11-9-18/h1-7,12,22H,8-11H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human MMP8 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay				J Med Chem 53: 6653-80 (2010) Article DOI: 10.1021/jm100669j BindingDB Entry DOI: 10.7270/Q2KH0NQB
					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50348675 (CHEMBL1801045) Show SMILES ONC(=O)C1(CCOCC1)S(=O)(=O)c1ccc(Oc2cccc(Cl)c2)cc1 Show InChI InChI=1S/C18H18ClNO6S/c19-13-2-1-3-15(12-13)26-14-4-6-16(7-5-14)27(23,24)18(17(21)20-22)8-10-25-11-9-18/h1-7,12,22H,8-11H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human MMP1 expressed in human HT-1080 cells assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluoromet...				J Med Chem 53: 6653-80 (2010) Article DOI: 10.1021/jm100669j BindingDB Entry DOI: 10.7270/Q2KH0NQB
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50348675 (CHEMBL1801045) Show SMILES ONC(=O)C1(CCOCC1)S(=O)(=O)c1ccc(Oc2cccc(Cl)c2)cc1 Show InChI InChI=1S/C18H18ClNO6S/c19-13-2-1-3-15(12-13)26-14-4-6-16(7-5-14)27(23,24)18(17(21)20-22)8-10-25-11-9-18/h1-7,12,22H,8-11H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay				J Med Chem 53: 6653-80 (2010) Article DOI: 10.1021/jm100669j BindingDB Entry DOI: 10.7270/Q2KH0NQB
					More data for this Ligand-Target Pair
Collagenase 3 (Homo sapiens (Human))	BDBM50348675 (CHEMBL1801045) Show SMILES ONC(=O)C1(CCOCC1)S(=O)(=O)c1ccc(Oc2cccc(Cl)c2)cc1 Show InChI InChI=1S/C18H18ClNO6S/c19-13-2-1-3-15(12-13)26-14-4-6-16(7-5-14)27(23,24)18(17(21)20-22)8-10-25-11-9-18/h1-7,12,22H,8-11H2,(H,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.450	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human MMP13 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay				J Med Chem 53: 6653-80 (2010) Article DOI: 10.1021/jm100669j BindingDB Entry DOI: 10.7270/Q2KH0NQB
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50348675 (CHEMBL1801045) Show SMILES ONC(=O)C1(CCOCC1)S(=O)(=O)c1ccc(Oc2cccc(Cl)c2)cc1 Show InChI InChI=1S/C18H18ClNO6S/c19-13-2-1-3-15(12-13)26-14-4-6-16(7-5-14)27(23,24)18(17(21)20-22)8-10-25-11-9-18/h1-7,12,22H,8-11H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human MMP3 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay				J Med Chem 53: 6653-80 (2010) Article DOI: 10.1021/jm100669j BindingDB Entry DOI: 10.7270/Q2KH0NQB
					More data for this Ligand-Target Pair