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SMILES: CCC(CC)Nc1nc(CC)c(nc1CC)-c1ccc(OC)nc1OC

InChI Key: InChIKey=GJYLEJKYONHKBE-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50348812   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50348812
PNG
(CHEMBL1806958)
Show SMILES CCC(CC)Nc1nc(CC)c(nc1CC)-c1ccc(OC)nc1OC
Show InChI InChI=1S/C20H30N4O2/c1-7-13(8-2)21-19-16(10-4)22-18(15(9-3)23-19)14-11-12-17(25-5)24-20(14)26-6/h11-13H,7-10H2,1-6H3,(H,21,23)
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PubMed
 11.6n/an/an/an/an/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Displacement of [125I]-sauvagine from human CRF-1 receptor expressed in human IMR-32 cells after 2 hrs by scintillation counting

J Med Chem 54: 4187-206 (2011)


Article DOI: 10.1021/jm200365y
BindingDB Entry DOI: 10.7270/Q2XS5VR1
More data for this
Ligand-Target Pair