BDBM50349016 CHEMBL1807484

SMILES: CN1CCN(CC1)c1cc(Nc2cc(n[nH]2)-c2cccc(NS(=O)(=O)c3cccc(C)c3)c2)nc(C)n1

InChI Key: InChIKey=ZEFQETLZQIQBNG-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50349016   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50349016 (CHEMBL1807484) Show SMILES CN1CCN(CC1)c1cc(Nc2cc(n[nH]2)-c2cccc(NS(=O)(=O)c3cccc(C)c3)c2)nc(C)n1 Show InChI InChI=1S/C26H30N8O2S/c1-18-6-4-9-22(14-18)37(35,36)32-21-8-5-7-20(15-21)23-16-25(31-30-23)29-24-17-26(28-19(2)27-24)34-12-10-33(3)11-13-34/h4-9,14-17,32H,10-13H2,1-3H3,(H2,27,28,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged VEGFR1 expressed in Sf9 insect cells after 120 mins by Kinase-Glo assay				Bioorg Med Chem 19: 4173-82 (2011) Article DOI: 10.1016/j.bmc.2011.06.016 BindingDB Entry DOI: 10.7270/Q2CR5TQV
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50349016 (CHEMBL1807484) Show SMILES CN1CCN(CC1)c1cc(Nc2cc(n[nH]2)-c2cccc(NS(=O)(=O)c3cccc(C)c3)c2)nc(C)n1 Show InChI InChI=1S/C26H30N8O2S/c1-18-6-4-9-22(14-18)37(35,36)32-21-8-5-7-20(15-21)23-16-25(31-30-23)29-24-17-26(28-19(2)27-24)34-12-10-33(3)11-13-34/h4-9,14-17,32H,10-13H2,1-3H3,(H2,27,28,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of GST-tagged FLT3 expressing wild type kinase domain expressed in Sf9 insect cells after 4 hrs by Kinase-Glo assay				Bioorg Med Chem 19: 4173-82 (2011) Article DOI: 10.1016/j.bmc.2011.06.016 BindingDB Entry DOI: 10.7270/Q2CR5TQV
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50349016 (CHEMBL1807484) Show SMILES CN1CCN(CC1)c1cc(Nc2cc(n[nH]2)-c2cccc(NS(=O)(=O)c3cccc(C)c3)c2)nc(C)n1 Show InChI InChI=1S/C26H30N8O2S/c1-18-6-4-9-22(14-18)37(35,36)32-21-8-5-7-20(15-21)23-16-25(31-30-23)29-24-17-26(28-19(2)27-24)34-12-10-33(3)11-13-34/h4-9,14-17,32H,10-13H2,1-3H3,(H2,27,28,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged Aurora A expressed in Sf9 insect cells after 90 mins by Kinase-Glo assay				Bioorg Med Chem 19: 4173-82 (2011) Article DOI: 10.1016/j.bmc.2011.06.016 BindingDB Entry DOI: 10.7270/Q2CR5TQV
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50349016 (CHEMBL1807484) Show SMILES CN1CCN(CC1)c1cc(Nc2cc(n[nH]2)-c2cccc(NS(=O)(=O)c3cccc(C)c3)c2)nc(C)n1 Show InChI InChI=1S/C26H30N8O2S/c1-18-6-4-9-22(14-18)37(35,36)32-21-8-5-7-20(15-21)23-16-25(31-30-23)29-24-17-26(28-19(2)27-24)34-12-10-33(3)11-13-34/h4-9,14-17,32H,10-13H2,1-3H3,(H2,27,28,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged VEGFR2 expressed in Sf9 insect cells after 120 mins by Kinase-Glo assay				Bioorg Med Chem 19: 4173-82 (2011) Article DOI: 10.1016/j.bmc.2011.06.016 BindingDB Entry DOI: 10.7270/Q2CR5TQV
					More data for this Ligand-Target Pair