Found 4 hits for monomerid = 50349096 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Dual specificity protein kinase TTK
(Homo sapiens (Human)) | BDBM50349096
(CHEMBL1808334)Show SMILES CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccccc3)nc-21 Show InChI InChI=1S/C27H28N6O/c1-4-17-10-9-11-18(5-2)22(17)30-26(34)24-21-15-14-19-16-28-27(29-20-12-7-6-8-13-20)31-23(19)25(21)33(3)32-24/h6-13,16H,4-5,14-15H2,1-3H3,(H,30,34)(H,28,29,31) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description
Inhibition of MPS1 assessed as [33P]-gamma-ATP incorporation into substrate P38-betatide by gamma counting |
Bioorg Med Chem Lett 21: 4507-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.122
BindingDB Entry DOI: 10.7270/Q2R211RS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50349096
(CHEMBL1808334)Show SMILES CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccccc3)nc-21 Show InChI InChI=1S/C27H28N6O/c1-4-17-10-9-11-18(5-2)22(17)30-26(34)24-21-15-14-19-16-28-27(29-20-12-7-6-8-13-20)31-23(19)25(21)33(3)32-24/h6-13,16H,4-5,14-15H2,1-3H3,(H,30,34)(H,28,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description
Inhibition of PLK1 assessed as [33P]-gamma-ATP incorporation into substrate by gamma counting |
Bioorg Med Chem Lett 21: 4507-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.122
BindingDB Entry DOI: 10.7270/Q2R211RS |
More data for this
Ligand-Target Pair | |
Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50349096
(CHEMBL1808334)Show SMILES CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccccc3)nc-21 Show InChI InChI=1S/C27H28N6O/c1-4-17-10-9-11-18(5-2)22(17)30-26(34)24-21-15-14-19-16-28-27(29-20-12-7-6-8-13-20)31-23(19)25(21)33(3)32-24/h6-13,16H,4-5,14-15H2,1-3H3,(H,30,34)(H,28,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description
Inhibition of CDK2/Cyclin A assessed as [33P]-gamma-ATP incorporation into substrate by gamma counting |
Bioorg Med Chem Lett 21: 4507-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.122
BindingDB Entry DOI: 10.7270/Q2R211RS |
More data for this
Ligand-Target Pair | |
Aurora kinase A
(Homo sapiens (Human)) | BDBM50349096
(CHEMBL1808334)Show SMILES CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccccc3)nc-21 Show InChI InChI=1S/C27H28N6O/c1-4-17-10-9-11-18(5-2)22(17)30-26(34)24-21-15-14-19-16-28-27(29-20-12-7-6-8-13-20)31-23(19)25(21)33(3)32-24/h6-13,16H,4-5,14-15H2,1-3H3,(H,30,34)(H,28,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 152 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description
Inhibition of Aur-A assessed as [33P]-gamma-ATP incorporation into substrate by gamma counting |
Bioorg Med Chem Lett 21: 4507-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.122
BindingDB Entry DOI: 10.7270/Q2R211RS |
More data for this
Ligand-Target Pair | |
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