Found 4 hits for monomerid = 50349099 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Dual specificity protein kinase TTK
(Homo sapiens (Human)) | BDBM50349099
(CHEMBL1808338)Show SMILES CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC)C(N)=O)nc-21 Show InChI InChI=1S/C29H31N7O3/c1-5-16-8-7-9-17(6-2)23(16)33-28(38)25-20-12-10-19-15-31-29(34-24(19)26(20)36(3)35-25)32-21-13-11-18(27(30)37)14-22(21)39-4/h7-9,11,13-15H,5-6,10,12H2,1-4H3,(H2,30,37)(H,33,38)(H,31,32,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description
Inhibition of MPS1 assessed as [33P]-gamma-ATP incorporation into substrate P38-betatide by gamma counting |
Bioorg Med Chem Lett 21: 4507-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.122
BindingDB Entry DOI: 10.7270/Q2R211RS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50349099
(CHEMBL1808338)Show SMILES CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC)C(N)=O)nc-21 Show InChI InChI=1S/C29H31N7O3/c1-5-16-8-7-9-17(6-2)23(16)33-28(38)25-20-12-10-19-15-31-29(34-24(19)26(20)36(3)35-25)32-21-13-11-18(27(30)37)14-22(21)39-4/h7-9,11,13-15H,5-6,10,12H2,1-4H3,(H2,30,37)(H,33,38)(H,31,32,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description
Inhibition of PLK1 assessed as [33P]-gamma-ATP incorporation into substrate by gamma counting |
Bioorg Med Chem Lett 21: 4507-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.122
BindingDB Entry DOI: 10.7270/Q2R211RS |
More data for this
Ligand-Target Pair | |
Cyclin-Dependent Kinase 2 (CDK2)
(Homo sapiens (Human)) | BDBM50349099
(CHEMBL1808338)Show SMILES CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC)C(N)=O)nc-21 Show InChI InChI=1S/C29H31N7O3/c1-5-16-8-7-9-17(6-2)23(16)33-28(38)25-20-12-10-19-15-31-29(34-24(19)26(20)36(3)35-25)32-21-13-11-18(27(30)37)14-22(21)39-4/h7-9,11,13-15H,5-6,10,12H2,1-4H3,(H2,30,37)(H,33,38)(H,31,32,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.57E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description
Inhibition of CDK2/Cyclin A assessed as [33P]-gamma-ATP incorporation into substrate by gamma counting |
Bioorg Med Chem Lett 21: 4507-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.122
BindingDB Entry DOI: 10.7270/Q2R211RS |
More data for this
Ligand-Target Pair | |
Aurora kinase A
(Homo sapiens (Human)) | BDBM50349099
(CHEMBL1808338)Show SMILES CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC)C(N)=O)nc-21 Show InChI InChI=1S/C29H31N7O3/c1-5-16-8-7-9-17(6-2)23(16)33-28(38)25-20-12-10-19-15-31-29(34-24(19)26(20)36(3)35-25)32-21-13-11-18(27(30)37)14-22(21)39-4/h7-9,11,13-15H,5-6,10,12H2,1-4H3,(H2,30,37)(H,33,38)(H,31,32,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 768 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description
Inhibition of Aur-A assessed as [33P]-gamma-ATP incorporation into substrate by gamma counting |
Bioorg Med Chem Lett 21: 4507-11 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.122
BindingDB Entry DOI: 10.7270/Q2R211RS |
More data for this
Ligand-Target Pair | |
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