BDBM50349545 CHEMBL1808900

SMILES: Cc1cc(ncc1C1CC(F)CN1C(=O)C1CCC1)-c1cccc(Cl)c1

InChI Key: InChIKey=BPICUEHAJGKYLS-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50349545   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50349545 (CHEMBL1808900) Show SMILES Cc1cc(ncc1C1CC(F)CN1C(=O)C1CCC1)-c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClFN2O/c1-13-8-19(15-6-3-7-16(22)9-15)24-11-18(13)20-10-17(23)12-25(20)21(26)14-4-2-5-14/h3,6-9,11,14,17,20H,2,4-5,10,12H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lundbeck Research USA, Inc. Curated by ChEMBL					Assay Description Displacement of [3H]-MPEP from human mGluR5 expressed in CHO cells after 60 mins				Bioorg Med Chem Lett 21: 4891-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.014 BindingDB Entry DOI: 10.7270/Q2CN748G
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50349545 (CHEMBL1808900) Show SMILES Cc1cc(ncc1C1CC(F)CN1C(=O)C1CCC1)-c1cccc(Cl)c1 Show InChI InChI=1S/C21H22ClFN2O/c1-13-8-19(15-6-3-7-16(22)9-15)24-11-18(13)20-10-17(23)12-25(20)21(26)14-4-2-5-14/h3,6-9,11,14,17,20H,2,4-5,10,12H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Lundbeck Research USA, Inc. Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilization aft...				Bioorg Med Chem Lett 21: 4891-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.014 BindingDB Entry DOI: 10.7270/Q2CN748G
					More data for this Ligand-Target Pair