null
SMILES: ClC1=C2OC=C(CC=C)c3cccc(C(=O)C1=O)c23
InChI Key: InChIKey=WTCAISUIYLUFAH-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM50349933 (CHEMBL1812144) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled pBR322 DNA after 30 mins by agarose gel electrophoresis | Eur J Med Chem 46: 3339-47 (2011) Article DOI: 10.1016/j.ejmech.2011.04.059 BindingDB Entry DOI: 10.7270/Q2513ZJD | |||||||||||
More data for this Ligand-Target Pair |