BDBM50350107 CHEMBL1230692
SMILES: Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)O[P@](O)(=O)OC[C@H]2NC[C@H](O)[C@@H]2O)[C@@H](O)[C@H]1O
InChI Key: InChIKey=NDQDTBCXPOIQGT-UHNJQBFTSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Poly(ADP-ribose) glycohydrolase (Rattus norvegicus) | BDBM50350107 (CHEMBL1230692) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto Health Science University Curated by ChEMBL | Assay Description Inhibition of rat testis GST-tagged PARG catalytic activity after 30 mins using [32P]poly(ADP-ribose) by radioassay | Bioorg Med Chem Lett 24: 3802-6 (2014) Article DOI: 10.1016/j.bmcl.2014.06.065 BindingDB Entry DOI: 10.7270/Q2348N18 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
poly(ADP-ribose) glycohydrolase (PARG) (Homo sapiens (Human)) | BDBM50350107 (CHEMBL1230692) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona Curated by ChEMBL | Assay Description Inhibition of PARG using [alpha-32P]ADP-ribose polymers after 5 mins by TRAP assay | J Med Chem 54: 5403-13 (2011) Article DOI: 10.1021/jm200325s BindingDB Entry DOI: 10.7270/Q2416XFG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] glycohydrolase (Bos taurus) | BDBM50350107 (CHEMBL1230692) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description The compound was tested for its ability to inhibit recombinant bovine polyadenosine diphosphoribose glycohydrolase catalytic fragment (rPARG-CF) | J Med Chem 46: 4322-32 (2003) Article DOI: 10.1021/jm020541u BindingDB Entry DOI: 10.7270/Q25M66FZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] glycohydrolase (Bos taurus) | BDBM50350107 (CHEMBL1230692) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description The compound was tested for its ability to inhibit bovine thymus polyadenosine diphosphoribose glycohydrolase (bPARG) | J Med Chem 46: 4322-32 (2003) Article DOI: 10.1021/jm020541u BindingDB Entry DOI: 10.7270/Q25M66FZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] glycohydrolase (Bos taurus) | BDBM50350107 (CHEMBL1230692) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky Curated by ChEMBL | Assay Description The compound was tested for its ability to inhibit recombinant bovine polyadenosine diphosphoribose glycohydrolase catalytic fragment (rPARG-CF) | J Med Chem 46: 4322-32 (2003) Article DOI: 10.1021/jm020541u BindingDB Entry DOI: 10.7270/Q25M66FZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM50350107 (CHEMBL1230692) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona Curated by ChEMBL | Assay Description Inhibition of PARP-1 using [32P]-NAD+ after 15 mins | J Med Chem 54: 5403-13 (2011) Article DOI: 10.1021/jm200325s BindingDB Entry DOI: 10.7270/Q2416XFG | |||||||||||
More data for this Ligand-Target Pair |