BDBM50351386 CHEMBL1819076

SMILES: CCC(CC)Nc1c2CCCc2nc2c(c(C)nn12)-c1c(C)cc(OC)cc1C

InChI Key: InChIKey=YFNGKGYGTYBNSY-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50351386   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50351386 (CHEMBL1819076) Show SMILES CCC(CC)Nc1c2CCCc2nc2c(c(C)nn12)-c1c(C)cc(OC)cc1C |(11.43,-13.22,;10.08,-13.96,;10.05,-15.5,;11.37,-16.3,;12.72,-15.55,;8.71,-16.25,;8.68,-17.79,;7.33,-18.53,;5.87,-18.03,;4.94,-19.26,;5.82,-20.52,;7.3,-20.08,;8.62,-20.87,;9.98,-20.11,;11.43,-20.61,;12.35,-19.37,;13.89,-19.39,;11.46,-18.12,;10,-18.58,;11.89,-22.08,;13.39,-22.41,;14.43,-21.27,;13.85,-23.87,;12.81,-25.01,;13.27,-26.48,;12.22,-27.62,;11.3,-24.67,;10.85,-23.21,;9.34,-22.87,)| Show InChI InChI=1S/C24H32N4O/c1-7-17(8-2)25-23-19-10-9-11-20(19)26-24-22(16(5)27-28(23)24)21-14(3)12-18(29-6)13-15(21)4/h12-13,17,25H,7-11H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP productio...				Bioorg Med Chem 19: 5432-45 (2011) Article DOI: 10.1016/j.bmc.2011.07.055 BindingDB Entry DOI: 10.7270/Q2Z038JX
					More data for this Ligand-Target Pair
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM50351386 (CHEMBL1819076) Show SMILES CCC(CC)Nc1c2CCCc2nc2c(c(C)nn12)-c1c(C)cc(OC)cc1C |(11.43,-13.22,;10.08,-13.96,;10.05,-15.5,;11.37,-16.3,;12.72,-15.55,;8.71,-16.25,;8.68,-17.79,;7.33,-18.53,;5.87,-18.03,;4.94,-19.26,;5.82,-20.52,;7.3,-20.08,;8.62,-20.87,;9.98,-20.11,;11.43,-20.61,;12.35,-19.37,;13.89,-19.39,;11.46,-18.12,;10,-18.58,;11.89,-22.08,;13.39,-22.41,;14.43,-21.27,;13.85,-23.87,;12.81,-25.01,;13.27,-26.48,;12.22,-27.62,;11.3,-24.67,;10.85,-23.21,;9.34,-22.87,)| Show InChI InChI=1S/C24H32N4O/c1-7-17(8-2)25-23-19-10-9-11-20(19)26-24-22(16(5)27-28(23)24)21-14(3)12-18(29-6)13-15(21)4/h12-13,17,25H,7-11H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells after 2 hrs by gamma counting				Bioorg Med Chem 19: 5432-45 (2011) Article DOI: 10.1016/j.bmc.2011.07.055 BindingDB Entry DOI: 10.7270/Q2Z038JX
					More data for this Ligand-Target Pair