BDBM50352530 CHEMBL1824874

SMILES: Nc1ncc(cc1OCc1c(F)cccc1Cl)-c1ccc(cc1)C(=O)N1CCC[C@@H]1CN1CCCC1

InChI Key: InChIKey=LDEBBWLEDFNOEV-JOCHJYFZSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50352530   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50352530 (CHEMBL1824874) Show SMILES Nc1ncc(cc1OCc1c(F)cccc1Cl)-c1ccc(cc1)C(=O)N1CCC[C@@H]1CN1CCCC1 |r| Show InChI InChI=1S/C28H30ClFN4O2/c29-24-6-3-7-25(30)23(24)18-36-26-15-21(16-32-27(26)31)19-8-10-20(11-9-19)28(35)34-14-4-5-22(34)17-33-12-1-2-13-33/h3,6-11,15-16,22H,1-2,4-5,12-14,17-18H2,(H2,31,32)/t22-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	5.11E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to human recombinant c-MET assessed as inhibition of autophosphorylation by continuous fluorometric assay				J Med Chem 54: 6342-63 (2011) Article DOI: 10.1021/jm2007613 BindingDB Entry DOI: 10.7270/Q2Q52Q09
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50352530 (CHEMBL1824874) Show SMILES Nc1ncc(cc1OCc1c(F)cccc1Cl)-c1ccc(cc1)C(=O)N1CCC[C@@H]1CN1CCCC1 |r| Show InChI InChI=1S/C28H30ClFN4O2/c29-24-6-3-7-25(30)23(24)18-36-26-15-21(16-32-27(26)31)19-8-10-20(11-9-19)28(35)34-14-4-5-22(34)17-33-12-1-2-13-33/h3,6-11,15-16,22H,1-2,4-5,12-14,17-18H2,(H2,31,32)/t22-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant c-MET kinase expressed in A549 cells assessed as inhibition of HGF-induced autophosphorylation by ELISA method				J Med Chem 54: 6342-63 (2011) Article DOI: 10.1021/jm2007613 BindingDB Entry DOI: 10.7270/Q2Q52Q09
					More data for this Ligand-Target Pair