Found 4 hits for monomerid = 50352870 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM50352870
(CHEMBL1824339)Show SMILES CC(C)n1cc(cn1)C1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cccnc1F |t:10| Show InChI InChI=1S/C21H20F2N6O/c1-12(2)29-11-14(10-26-29)21(19(30)28(3)20(24)27-21)13-6-7-17(22)16(9-13)15-5-4-8-25-18(15)23/h4-12H,1-3H3,(H2,24,27) | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 500 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of BACE1 expressed in CHO cells expressing wild type human APP assessed as inhibition of amyloid beta-40 or 42 production by ELISA assay |
Bioorg Med Chem Lett 21: 5164-70 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.057 BindingDB Entry DOI: 10.7270/Q2WQ045T |
More data for this Ligand-Target Pair | |
Cathepsin D
(Homo sapiens (Human)) | BDBM50352870
(CHEMBL1824339)Show SMILES CC(C)n1cc(cn1)C1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cccnc1F |t:10| Show InChI InChI=1S/C21H20F2N6O/c1-12(2)29-11-14(10-26-29)21(19(30)28(3)20(24)27-21)13-6-7-17(22)16(9-13)15-5-4-8-25-18(15)23/h4-12H,1-3H3,(H2,24,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.85E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of cathepsin D by FRET assay |
Bioorg Med Chem Lett 21: 5164-70 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.057 BindingDB Entry DOI: 10.7270/Q2WQ045T |
More data for this Ligand-Target Pair | |
Beta-secretase 2
(Homo sapiens (Human)) | BDBM50352870
(CHEMBL1824339)Show SMILES CC(C)n1cc(cn1)C1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cccnc1F |t:10| Show InChI InChI=1S/C21H20F2N6O/c1-12(2)29-11-14(10-26-29)21(19(30)28(3)20(24)27-21)13-6-7-17(22)16(9-13)15-5-4-8-25-18(15)23/h4-12H,1-3H3,(H2,24,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of BACE2 by FRET assay |
Bioorg Med Chem Lett 21: 5164-70 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.057 BindingDB Entry DOI: 10.7270/Q2WQ045T |
More data for this Ligand-Target Pair | |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM50352870
(CHEMBL1824339)Show SMILES CC(C)n1cc(cn1)C1(N=C(N)N(C)C1=O)c1ccc(F)c(c1)-c1cccnc1F |t:10| Show InChI InChI=1S/C21H20F2N6O/c1-12(2)29-11-14(10-26-29)21(19(30)28(3)20(24)27-21)13-6-7-17(22)16(9-13)15-5-4-8-25-18(15)23/h4-12H,1-3H3,(H2,24,27) | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of BACE1 by FRET assay |
Bioorg Med Chem Lett 21: 5164-70 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.057 BindingDB Entry DOI: 10.7270/Q2WQ045T |
More data for this Ligand-Target Pair | |