BDBM50353018 CHEMBL1821980::CHEMBL1852660
SMILES: NC1CCc2c(Br)ccc(-c3ccccc3)c2CC1=O
InChI Key: InChIKey=XFZZDIHCNHYESF-UHFFFAOYSA-N
Data: 7 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aminopeptidase N (Sus scrofa (Pig)) | BDBM50353018 (CHEMBL1821980 | CHEMBL1852660) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Haute Alsace Curated by ChEMBL | Assay Description Inhibition of porcine kidney APN using L-leucine-p-nitroanilide as substrate after 30 mins by Dixon plot analysis | Bioorg Med Chem 19: 5716-33 (2011) Article DOI: 10.1016/j.bmc.2011.06.089 BindingDB Entry DOI: 10.7270/Q2805307 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Homo sapiens (Human)) | BDBM50353018 (CHEMBL1821980 | CHEMBL1852660) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Haute Alsace Curated by ChEMBL | Assay Description Inhibition of human APN | Bioorg Med Chem 23: 3192-207 (2015) BindingDB Entry DOI: 10.7270/Q2Z321DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM50353018 (CHEMBL1821980 | CHEMBL1852660) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Haute-Alsace Curated by ChEMBL | Assay Description Inhibition of pig APN using L-leucine-p-nitroanilide as substrate measured every 10 mins for 2 hrs by spectriphotometric analysis | Bioorg Med Chem 21: 2135-44 (2013) Article DOI: 10.1016/j.bmc.2012.12.038 BindingDB Entry DOI: 10.7270/Q2CZ38J9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Mus musculus) | BDBM50353018 (CHEMBL1821980 | CHEMBL1852660) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Haute-Alsace Curated by ChEMBL | Assay Description Inhibition of mouse APN using L-leucine-p-nitroanilide as substrate measured every 10 mins for 2 hrs by spectriphotometric analysis | Bioorg Med Chem 21: 2135-44 (2013) Article DOI: 10.1016/j.bmc.2012.12.038 BindingDB Entry DOI: 10.7270/Q2CZ38J9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Homo sapiens (Human)) | BDBM50353018 (CHEMBL1821980 | CHEMBL1852660) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.350 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Haute-Alsace Curated by ChEMBL | Assay Description Inhibition of human APN using L-leucine-p-nitroanilide as substrate measured every 10 mins for 2 hrs by spectriphotometric analysis | Bioorg Med Chem 21: 2135-44 (2013) Article DOI: 10.1016/j.bmc.2012.12.038 BindingDB Entry DOI: 10.7270/Q2CZ38J9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bacterial leucyl aminopeptidase (Vibrio proteolyticus) | BDBM50353018 (CHEMBL1821980 | CHEMBL1852660) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Haute Alsace Curated by ChEMBL | Assay Description Inhibition of Aeromonas proteolytica aminopeptidase using L-leucine-p-nitroanilide as substrate after 30 mins by Dixon plot analysis | Bioorg Med Chem 19: 5716-33 (2011) Article DOI: 10.1016/j.bmc.2011.06.089 BindingDB Entry DOI: 10.7270/Q2805307 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytosol aminopeptidase (Bos taurus (bovine)) | BDBM50353018 (CHEMBL1821980 | CHEMBL1852660) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 7.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Haute Alsace Curated by ChEMBL | Assay Description Inhibition of bovine kidney cytosolic leucine aminopeptidase using L-leucine-p-nitroanilide as substrate after 30 mins by Dixon plot analysis | Bioorg Med Chem 19: 5716-33 (2011) Article DOI: 10.1016/j.bmc.2011.06.089 BindingDB Entry DOI: 10.7270/Q2805307 | |||||||||||
More data for this Ligand-Target Pair |