BDBM50353846 CHEMBL1831156::US9604926, Compound CM-338::US9724435, Compound CM-338

SMILES: Fc1ccc(cc1)N1CCN(CCCCn2ccc3ccccc23)CC1

InChI Key: InChIKey=KRXYVKJBVSRNHI-UHFFFAOYSA-N

Data: 5 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50353846   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sigma-2 receptor (Rattus norvegicus (Rat))	BDBM50353846 (CHEMBL1831156 | US9604926, Compound CM-338 | US972...) Show SMILES Fc1ccc(cc1)N1CCN(CCCCn2ccc3ccccc23)CC1 Show InChI InChI=1S/C22H26FN3/c23-20-7-9-21(10-8-20)25-17-15-24(16-18-25)12-3-4-13-26-14-11-19-5-1-2-6-22(19)26/h1-2,5-11,14H,3-4,12-13,15-18H2	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	1.09	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
THE UNIVERSITY OF MISSISSIPPI; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY US Patent					Assay Description Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...				US Patent US9724435 (2017) BindingDB Entry DOI: 10.7270/Q2BZ6856
					More data for this Ligand-Target Pair
Sigma intracellular receptor 2 (Mus musculus (Mouse))	BDBM50353846 (CHEMBL1831156 | US9604926, Compound CM-338 | US972...) Show SMILES Fc1ccc(cc1)N1CCN(CCCCn2ccc3ccccc23)CC1 Show InChI InChI=1S/C22H26FN3/c23-20-7-9-21(10-8-20)25-17-15-24(16-18-25)12-3-4-13-26-14-11-19-5-1-2-6-22(19)26/h1-2,5-11,14H,3-4,12-13,15-18H2	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	1.09	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
THE UNIVERSITY OF MISSISSIPPI US Patent					Assay Description Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...				US Patent US9604926 (2017) BindingDB Entry DOI: 10.7270/Q27D2X6J
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50353846 (CHEMBL1831156 | US9604926, Compound CM-338 | US972...) Show SMILES Fc1ccc(cc1)N1CCN(CCCCn2ccc3ccccc23)CC1 Show InChI InChI=1S/C22H26FN3/c23-20-7-9-21(10-8-20)25-17-15-24(16-18-25)12-3-4-13-26-14-11-19-5-1-2-6-22(19)26/h1-2,5-11,14H,3-4,12-13,15-18H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	71.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Mississippi Curated by ChEMBL					Assay Description Displacement of (-)-[3H]pentazocine from sigma 1 receptor in rat brain membrane after 120 mins				Eur J Med Chem 46: 5154-61 (2011) Article DOI: 10.1016/j.ejmech.2011.08.031 BindingDB Entry DOI: 10.7270/Q2PV6KRM
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Mus musculus (Mouse))	BDBM50353846 (CHEMBL1831156 | US9604926, Compound CM-338 | US972...) Show SMILES Fc1ccc(cc1)N1CCN(CCCCn2ccc3ccccc23)CC1 Show InChI InChI=1S/C22H26FN3/c23-20-7-9-21(10-8-20)25-17-15-24(16-18-25)12-3-4-13-26-14-11-19-5-1-2-6-22(19)26/h1-2,5-11,14H,3-4,12-13,15-18H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	170	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
THE UNIVERSITY OF MISSISSIPPI US Patent					Assay Description Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...				US Patent US9604926 (2017) BindingDB Entry DOI: 10.7270/Q27D2X6J
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50353846 (CHEMBL1831156 | US9604926, Compound CM-338 | US972...) Show SMILES Fc1ccc(cc1)N1CCN(CCCCn2ccc3ccccc23)CC1 Show InChI InChI=1S/C22H26FN3/c23-20-7-9-21(10-8-20)25-17-15-24(16-18-25)12-3-4-13-26-14-11-19-5-1-2-6-22(19)26/h1-2,5-11,14H,3-4,12-13,15-18H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	170	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
THE UNIVERSITY OF MISSISSIPPI; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY US Patent					Assay Description Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...				US Patent US9724435 (2017) BindingDB Entry DOI: 10.7270/Q2BZ6856
					More data for this Ligand-Target Pair