Found 3 hits for monomerid = 50353940 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50353940
(CHEMBL1828653)Show SMILES Fc1cccc2N(c3ccccc3F)S(=O)(=O)N(CCC3CNCCO3)c12 Show InChI InChI=1S/C18H19F2N3O3S/c19-14-4-1-2-6-16(14)23-17-7-3-5-15(20)18(17)22(27(23,24)25)10-8-13-12-21-9-11-26-13/h1-7,13,21H,8-12H2 | Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human NET expressed in MDCK-Net6 cells assessed as inhibition of norepinephrine uptake |
J Med Chem 54: 6824-31 (2011)
Article DOI: 10.1021/jm200733r BindingDB Entry DOI: 10.7270/Q2XD1227 |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50353940
(CHEMBL1828653)Show SMILES Fc1cccc2N(c3ccccc3F)S(=O)(=O)N(CCC3CNCCO3)c12 Show InChI InChI=1S/C18H19F2N3O3S/c19-14-4-1-2-6-16(14)23-17-7-3-5-15(20)18(17)22(27(23,24)25)10-8-13-12-21-9-11-26-13/h1-7,13,21H,8-12H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 992 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human SERT expressed in JAR cells assessed as serotonin uptake |
J Med Chem 54: 6824-31 (2011)
Article DOI: 10.1021/jm200733r BindingDB Entry DOI: 10.7270/Q2XD1227 |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50353940
(CHEMBL1828653)Show SMILES Fc1cccc2N(c3ccccc3F)S(=O)(=O)N(CCC3CNCCO3)c12 Show InChI InChI=1S/C18H19F2N3O3S/c19-14-4-1-2-6-16(14)23-17-7-3-5-15(20)18(17)22(27(23,24)25)10-8-13-12-21-9-11-26-13/h1-7,13,21H,8-12H2 | Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 54: 6824-31 (2011)
Article DOI: 10.1021/jm200733r BindingDB Entry DOI: 10.7270/Q2XD1227 |
More data for this Ligand-Target Pair | |