BDBM50354120 CHEMBL1836239

SMILES: CCOc1ccccc1-n1c(CN2CCCNCC2)nc2ccccc2c1=O

InChI Key: InChIKey=KQKLUZQUFDIROG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50354120   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50354120 (CHEMBL1836239) Show SMILES CCOc1ccccc1-n1c(CN2CCCNCC2)nc2ccccc2c1=O |(5.33,.53,;4,-.24,;2.67,.53,;2.67,2.07,;4,2.84,;4,4.38,;2.67,5.15,;1.33,4.38,;1.33,2.84,;,2.07,;,.53,;1.33,-.24,;1.33,-1.78,;2.72,-2.45,;3.06,-3.95,;2.1,-5.15,;.56,-5.15,;-.4,-3.95,;-.05,-2.45,;-1.33,-.24,;-2.67,.53,;-4,-.24,;-5.33,.53,;-5.33,2.07,;-4,2.84,;-2.67,2.07,;-1.33,2.84,;-1.33,4.38,)| Show InChI InChI=1S/C22H26N4O2/c1-2-28-20-11-6-5-10-19(20)26-21(16-25-14-7-12-23-13-15-25)24-18-9-4-3-8-17(18)22(26)27/h3-6,8-11,23H,2,7,12-16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
National Human Genome Research Institute Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1alpha activation in human ME180 cells by HRE3-Bla-luciferase reporter gene assay				Bioorg Med Chem Lett 21: 5239-43 (2011) Article DOI: 10.1016/j.bmcl.2011.07.043 BindingDB Entry DOI: 10.7270/Q2H70G65
					More data for this Ligand-Target Pair