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SMILES: CCOc1ccccc1-n1c(CN2CCN(CC2)C(=O)c2ccco2)nc2ccccc2c1=O

InChI Key: InChIKey=LHDOHFGVTGMBDX-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50354125   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50354125
PNG
(CHEMBL1345685)
Show SMILES CCOc1ccccc1-n1c(CN2CCN(CC2)C(=O)c2ccco2)nc2ccccc2c1=O |(-1.34,-9.62,;-2.67,-8.85,;-2.67,-7.31,;-4.01,-6.54,;-5.34,-7.31,;-6.67,-6.54,;-6.67,-5,;-5.34,-4.23,;-4.01,-5,;-2.67,-4.23,;-2.67,-2.69,;-4.01,-1.92,;-4.01,-.38,;-5.34,.39,;-5.34,1.93,;-4.01,2.7,;-2.67,1.93,;-2.67,.39,;-4.01,4.24,;-5.34,5.01,;-2.67,5.01,;-2.51,6.54,;-1,6.86,;-.23,5.53,;-1.27,4.38,;-1.34,-1.92,;-0,-2.69,;1.33,-1.92,;2.66,-2.69,;2.66,-4.23,;1.33,-5,;-0,-4.23,;-1.34,-5,;-1.34,-6.54,)|
Show InChI InChI=1S/C26H26N4O4/c1-2-33-22-11-6-5-10-21(22)30-24(27-20-9-4-3-8-19(20)25(30)31)18-28-13-15-29(16-14-28)26(32)23-12-7-17-34-23/h3-12,17H,2,13-16,18H2,1H3
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Article
PubMed
n/an/a 430n/an/an/an/an/an/a



National Human Genome Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha activation in human ME180 cells by HRE3-Bla-luciferase reporter gene assay

Bioorg Med Chem Lett 21: 5239-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.043
BindingDB Entry DOI: 10.7270/Q2H70G65
More data for this
Ligand-Target Pair