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SMILES: O=c1n(c(CN2CCNCC2)nc2ccccc12)-c1ccccc1OCc1ccccc1

InChI Key: InChIKey=NNFABBAAEQFFAN-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50354131   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50354131
PNG
(CHEMBL1836182)
Show SMILES O=c1n(c(CN2CCNCC2)nc2ccccc12)-c1ccccc1OCc1ccccc1 |(-2.67,4.23,;-2.67,2.7,;-1.33,1.93,;-1.33,.38,;,-.39,;,-1.93,;-1.33,-2.7,;-1.33,-4.23,;,-5.01,;1.33,-4.24,;1.33,-2.7,;-2.67,-.39,;-4,.38,;-5.33,-.39,;-6.67,.38,;-6.67,1.93,;-5.33,2.7,;-4,1.93,;,2.7,;,4.23,;1.33,5.01,;2.67,4.23,;2.67,2.7,;1.33,1.93,;1.33,.38,;2.67,-.38,;4,.38,;5.33,-.38,;6.67,.38,;6.67,1.93,;5.33,2.7,;4,1.93,)|
Show InChI InChI=1S/C26H26N4O2/c31-26-21-10-4-5-11-22(21)28-25(18-29-16-14-27-15-17-29)30(26)23-12-6-7-13-24(23)32-19-20-8-2-1-3-9-20/h1-13,27H,14-19H2
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Article
PubMed
n/an/a 2.29E+4n/an/an/an/an/an/a



National Human Genome Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha activation in human ME180 cells by HRE3-Bla-luciferase reporter gene assay

Bioorg Med Chem Lett 21: 5239-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.043
BindingDB Entry DOI: 10.7270/Q2H70G65
More data for this
Ligand-Target Pair