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SMILES: CCSc1ccccc1-n1c(CN2CCNCC2)nc2ccccc2c1=O

InChI Key: InChIKey=HHVZITOLHMONBI-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50354133   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))		BDBM50354133
PNG
(CHEMBL1836184)
Show SMILES CCSc1ccccc1-n1c(CN2CCNCC2)nc2ccccc2c1=O |(5.33,.38,;4,-.38,;2.67,.38,;2.67,1.93,;4,2.7,;4,4.23,;2.67,5.01,;1.33,4.23,;1.33,2.7,;,1.93,;,.38,;1.33,-.39,;1.33,-1.93,;,-2.7,;,-4.23,;1.33,-5.01,;2.67,-4.24,;2.67,-2.7,;-1.33,-.39,;-2.67,.38,;-4,-.39,;-5.33,.38,;-5.33,1.93,;-4,2.7,;-2.67,1.93,;-1.33,2.7,;-1.33,4.23,)|
Show InChI InChI=1S/C21H24N4OS/c1-2-27-19-10-6-5-9-18(19)25-20(15-24-13-11-22-12-14-24)23-17-8-4-3-7-16(17)21(25)26/h3-10,22H,2,11-15H2,1H3
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n/an/a 3.50E+3n/an/an/an/an/an/a



National Human Genome Research Institute

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1alpha activation in human ME180 cells by HRE3-Bla-luciferase reporter gene assay

Bioorg Med Chem Lett 21: 5239-43 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.043
BindingDB Entry DOI: 10.7270/Q2H70G65
More data for this
Ligand-Target Pair