BDBM50354215 CHEMBL1835993
SMILES: CN([C@@H]1CCN(C1)C1CCC1)C(=O)c1ccc(Cn2c(C)nc3ccccc23)cc1
InChI Key: InChIKey=AIYLLDBNJZOQLD-JOCHJYFZSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50354215 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50354215
(CHEMBL1835993)Show SMILES CN([C@@H]1CCN(C1)C1CCC1)C(=O)c1ccc(Cn2c(C)nc3ccccc23)cc1 |r| Show InChI InChI=1S/C25H30N4O/c1-18-26-23-8-3-4-9-24(23)29(18)16-19-10-12-20(13-11-19)25(30)27(2)22-14-15-28(17-22)21-6-5-7-21/h3-4,8-13,21-22H,5-7,14-17H2,1-2H3/t22-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells |
Bioorg Med Chem Lett 21: 5957-60 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.061 BindingDB Entry DOI: 10.7270/Q2QN6753 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50354215
(CHEMBL1835993)Show SMILES CN([C@@H]1CCN(C1)C1CCC1)C(=O)c1ccc(Cn2c(C)nc3ccccc23)cc1 |r| Show InChI InChI=1S/C25H30N4O/c1-18-26-23-8-3-4-9-24(23)29(18)16-19-10-12-20(13-11-19)25(30)27(2)22-14-15-28(17-22)21-6-5-7-21/h3-4,8-13,21-22H,5-7,14-17H2,1-2H3/t22-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human ERG |
Bioorg Med Chem Lett 21: 5957-60 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.061 BindingDB Entry DOI: 10.7270/Q2QN6753 |
More data for this Ligand-Target Pair | |