BDBM50354254 CHEMBL1836506
SMILES: Clc1ccc(CSc2nc(SCc3ccccc3)nc(=O)[nH]2)cc1
InChI Key: InChIKey=ZGTXTQCWNZHCTO-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Cathepsin B (Homo sapiens (Human)) | BDBM50354254 (CHEMBL1836506) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Ljubljana Curated by ChEMBL | Assay Description Partial mixed-type inhibition of human recombinant cathepsin B assessed as formation of fluorescent degradation product AMC using Z-Arg-Arg-AMC as su... | Eur J Med Chem 46: 4648-56 (2011) Article DOI: 10.1016/j.ejmech.2011.08.005 BindingDB Entry DOI: 10.7270/Q2M045TJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin B (Homo sapiens (Human)) | BDBM50354254 (CHEMBL1836506) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Ljubljana Curated by ChEMBL | Assay Description Reversible inhibition of human recombinant cathepsin B assessed as formation of fluorescent degradation product AMC using Z-Arg-Arg-AMC as substrate ... | Eur J Med Chem 46: 4648-56 (2011) Article DOI: 10.1016/j.ejmech.2011.08.005 BindingDB Entry DOI: 10.7270/Q2M045TJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Topoisomerase I/II (Homo sapiens (Human)) | BDBM50354254 (CHEMBL1836506) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.19E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Slovenia; University of Ljubljana Curated by ChEMBL | Assay Description Inhibition of human topoisomerase 2alpha using supercoiled pNO1 plasmid as substrate after 30 mins by HTS assay | Eur J Med Chem 175: 330-348 (2019) Article DOI: 10.1016/j.ejmech.2019.04.055 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Topoisomerase II alpha (HuTopoIIα) (Homo sapiens (Human)) | BDBM50354254 (CHEMBL1836506) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.19E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Chemistry Curated by ChEMBL | Assay Description Inhibition of human DNA topoisomerase IIalpha using plasmid pNO1 as a substrate after 30 mins | Bioorg Med Chem 23: 4218-29 (2015) BindingDB Entry DOI: 10.7270/Q2RJ4M72 | |||||||||||
More data for this Ligand-Target Pair |