BDBM50355008 CHEMBL1834960

SMILES: OC(=O)c1cccc(CCc2ccc(cc2)S(=O)(=O)Nc2ccccn2)c1

InChI Key: InChIKey=BQPOAKBKJXVEIQ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50355008   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cystine/glutamate transporter (Homo sapiens (Human))	BDBM50355008 (CHEMBL1834960) Show SMILES OC(=O)c1cccc(CCc2ccc(cc2)S(=O)(=O)Nc2ccccn2)c1 Show InChI InChI=1S/C20H18N2O4S/c23-20(24)17-5-3-4-16(14-17)8-7-15-9-11-18(12-10-15)27(25,26)22-19-6-1-2-13-21-19/h1-6,9-14H,7-8H2,(H,21,22)(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of xCT-mediated cystein/glutamate transporter (unknown origin) assessed as reduction in L-[14C]cyctein uptake				Eur J Med Chem 163: 215-242 (2019) Article DOI: 10.1016/j.ejmech.2018.11.066
					More data for this Ligand-Target Pair
Cystine/glutamate transporter (Homo sapiens (Human))	BDBM50355008 (CHEMBL1834960) Show SMILES OC(=O)c1cccc(CCc2ccc(cc2)S(=O)(=O)Nc2ccccn2)c1 Show InChI InChI=1S/C20H18N2O4S/c23-20(24)17-5-3-4-16(14-17)8-7-15-9-11-18(12-10-15)27(25,26)22-19-6-1-2-13-21-19/h1-6,9-14H,7-8H2,(H,21,22)(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
Johns Hopkins University Curated by ChEMBL					Assay Description Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...				Bioorg Med Chem Lett 21: 6184-7 (2011) Article DOI: 10.1016/j.bmcl.2011.07.081 BindingDB Entry DOI: 10.7270/Q21V5FCR
					More data for this Ligand-Target Pair