Found 8 hits for monomerid = 50355121 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50355121
(CHEMBL1835783)Show InChI InChI=1S/C22H29N3O2/c1-24-22(26)20-8-5-7-19(20)21(23-24)17-9-11-18(12-10-17)27-16-6-15-25-13-3-2-4-14-25/h9-12H,2-8,13-16H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Cephalon, Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]-NAMH from human histamine H3 receptor expressed in CHO cells |
Bioorg Med Chem Lett 21: 6126-30 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.045 BindingDB Entry DOI: 10.7270/Q2T72JFP |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50355121
(CHEMBL1835783)Show InChI InChI=1S/C22H29N3O2/c1-24-22(26)20-8-5-7-19(20)21(23-24)17-9-11-18(12-10-17)27-16-6-15-25-13-3-2-4-14-25/h9-12H,2-8,13-16H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 4.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Cephalon, Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]-NAMH from rat histamine H3 receptor expressed in CHO cells |
Bioorg Med Chem Lett 21: 6126-30 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.045 BindingDB Entry DOI: 10.7270/Q2T72JFP |
More data for this Ligand-Target Pair | |
Cytochrome P450 2C19
(Homo sapiens (Human)) | BDBM50355121
(CHEMBL1835783)Show InChI InChI=1S/C22H29N3O2/c1-24-22(26)20-8-5-7-19(20)21(23-24)17-9-11-18(12-10-17)27-16-6-15-25-13-3-2-4-14-25/h9-12H,2-8,13-16H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cephalon, Inc.
Curated by ChEMBL
| Assay Description Inhibition of CYP2C19 |
Bioorg Med Chem Lett 21: 6126-30 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.045 BindingDB Entry DOI: 10.7270/Q2T72JFP |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50355121
(CHEMBL1835783)Show InChI InChI=1S/C22H29N3O2/c1-24-22(26)20-8-5-7-19(20)21(23-24)17-9-11-18(12-10-17)27-16-6-15-25-13-3-2-4-14-25/h9-12H,2-8,13-16H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a |
Cephalon, Inc.
Curated by ChEMBL
| Assay Description Inverse agonist activity at human histamine H3 receptor assessed as decrease of basal activity of [35S]GTPgammaS binding |
Bioorg Med Chem Lett 21: 6126-30 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.045 BindingDB Entry DOI: 10.7270/Q2T72JFP |
More data for this Ligand-Target Pair | |
Cytochrome P450 1A2
(Homo sapiens (Human)) | BDBM50355121
(CHEMBL1835783)Show InChI InChI=1S/C22H29N3O2/c1-24-22(26)20-8-5-7-19(20)21(23-24)17-9-11-18(12-10-17)27-16-6-15-25-13-3-2-4-14-25/h9-12H,2-8,13-16H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cephalon, Inc.
Curated by ChEMBL
| Assay Description Inhibition of CYP1A2 |
Bioorg Med Chem Lett 21: 6126-30 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.045 BindingDB Entry DOI: 10.7270/Q2T72JFP |
More data for this Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50355121
(CHEMBL1835783)Show InChI InChI=1S/C22H29N3O2/c1-24-22(26)20-8-5-7-19(20)21(23-24)17-9-11-18(12-10-17)27-16-6-15-25-13-3-2-4-14-25/h9-12H,2-8,13-16H2,1H3 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cephalon, Inc.
Curated by ChEMBL
| Assay Description Inhibition of CYP2D6 |
Bioorg Med Chem Lett 21: 6126-30 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.045 BindingDB Entry DOI: 10.7270/Q2T72JFP |
More data for this Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50355121
(CHEMBL1835783)Show InChI InChI=1S/C22H29N3O2/c1-24-22(26)20-8-5-7-19(20)21(23-24)17-9-11-18(12-10-17)27-16-6-15-25-13-3-2-4-14-25/h9-12H,2-8,13-16H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cephalon, Inc.
Curated by ChEMBL
| Assay Description Inhibition of CYP3A4 |
Bioorg Med Chem Lett 21: 6126-30 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.045 BindingDB Entry DOI: 10.7270/Q2T72JFP |
More data for this Ligand-Target Pair | |
Cytochrome P450 2C9
(Homo sapiens (Human)) | BDBM50355121
(CHEMBL1835783)Show InChI InChI=1S/C22H29N3O2/c1-24-22(26)20-8-5-7-19(20)21(23-24)17-9-11-18(12-10-17)27-16-6-15-25-13-3-2-4-14-25/h9-12H,2-8,13-16H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cephalon, Inc.
Curated by ChEMBL
| Assay Description Inhibition of CYP2C9 |
Bioorg Med Chem Lett 21: 6126-30 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.045 BindingDB Entry DOI: 10.7270/Q2T72JFP |
More data for this Ligand-Target Pair | |