BDBM50355144 CHEMBL1834554

SMILES: Nc1ncnc2OC[C@@H](Oc12)c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1

InChI Key: InChIKey=AOVBNRRYULZZSN-XJKCOSOUSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50355144   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human))	BDBM50355144 (CHEMBL1834554) Show SMILES Nc1ncnc2OC[C@@H](Oc12)c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:17.19,8.12,wD:20.23,(-9.01,-11.21,;-9,-12.75,;-10.33,-13.52,;-10.33,-15.06,;-9,-15.83,;-7.66,-15.07,;-6.32,-15.83,;-4.98,-15.05,;-4.98,-13.5,;-6.33,-12.72,;-7.67,-13.51,;-3.65,-12.74,;-2.32,-13.49,;-.99,-12.71,;-1.01,-11.17,;-2.36,-10.41,;-3.68,-11.2,;.31,-10.39,;.29,-8.85,;1.62,-8.07,;2.96,-8.82,;4.29,-8.04,;5.63,-8.8,;5.64,-10.34,;6.96,-8.02,;2.98,-10.36,;1.66,-11.14,)| Show InChI InChI=1S/C20H23N3O4/c21-19-18-20(23-11-22-19)26-10-16(27-18)15-7-5-14(6-8-15)13-3-1-12(2-4-13)9-17(24)25/h5-8,11-13,16H,1-4,9-10H2,(H,24,25)(H2,21,22,23)/t12-,13-,16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human DGAT-1-mediated triglyceride synthesis in the HT-29 cells by whole cell assay				Bioorg Med Chem Lett 21: 6122-5 (2011) Article DOI: 10.1016/j.bmcl.2011.08.028 BindingDB Entry DOI: 10.7270/Q2MK6D9B
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human))	BDBM50355144 (CHEMBL1834554) Show SMILES Nc1ncnc2OC[C@@H](Oc12)c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:17.19,8.12,wD:20.23,(-9.01,-11.21,;-9,-12.75,;-10.33,-13.52,;-10.33,-15.06,;-9,-15.83,;-7.66,-15.07,;-6.32,-15.83,;-4.98,-15.05,;-4.98,-13.5,;-6.33,-12.72,;-7.67,-13.51,;-3.65,-12.74,;-2.32,-13.49,;-.99,-12.71,;-1.01,-11.17,;-2.36,-10.41,;-3.68,-11.2,;.31,-10.39,;.29,-8.85,;1.62,-8.07,;2.96,-8.82,;4.29,-8.04,;5.63,-8.8,;5.64,-10.34,;6.96,-8.02,;2.98,-10.36,;1.66,-11.14,)| Show InChI InChI=1S/C20H23N3O4/c21-19-18-20(23-11-22-19)26-10-16(27-18)15-7-5-14(6-8-15)13-3-1-12(2-4-13)9-17(24)25/h5-8,11-13,16H,1-4,9-10H2,(H,24,25)(H2,21,22,23)/t12-,13-,16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human DGAT1				Bioorg Med Chem Lett 21: 6122-5 (2011) Article DOI: 10.1016/j.bmcl.2011.08.028 BindingDB Entry DOI: 10.7270/Q2MK6D9B
					More data for this Ligand-Target Pair