BDBM50355149 CHEMBL1834558

SMILES: CC1(COc2ncnc(N)c2O1)c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1

InChI Key: InChIKey=PTURRLPBGFGSSH-OLZRQOMDSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50355149   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human))	BDBM50355149 (CHEMBL1834558) Show SMILES CC1(COc2ncnc(N)c2O1)c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:18.20,wD:21.24,(33.4,-24.14,;32.31,-23.06,;32.32,-24.61,;30.97,-25.39,;29.63,-24.62,;28.3,-25.39,;26.96,-24.62,;26.96,-23.08,;28.29,-22.31,;28.29,-20.77,;29.63,-23.07,;30.96,-22.28,;33.64,-22.29,;34.98,-23.05,;36.3,-22.27,;36.29,-20.73,;34.93,-19.97,;33.62,-20.76,;37.61,-19.95,;37.58,-18.41,;38.91,-17.62,;40.26,-18.38,;41.58,-17.6,;42.93,-18.36,;42.94,-19.9,;44.25,-17.58,;40.27,-19.92,;38.95,-20.7,)| Show InChI InChI=1S/C21H25N3O4/c1-21(11-27-20-18(28-21)19(22)23-12-24-20)16-8-6-15(7-9-16)14-4-2-13(3-5-14)10-17(25)26/h6-9,12-14H,2-5,10-11H2,1H3,(H,25,26)(H2,22,23,24)/t13-,14-,21?	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	735	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human DGAT-1-mediated triglyceride synthesis in the HT-29 cells by whole cell assay				Bioorg Med Chem Lett 21: 6122-5 (2011) Article DOI: 10.1016/j.bmcl.2011.08.028 BindingDB Entry DOI: 10.7270/Q2MK6D9B
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human))	BDBM50355149 (CHEMBL1834558) Show SMILES CC1(COc2ncnc(N)c2O1)c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:18.20,wD:21.24,(33.4,-24.14,;32.31,-23.06,;32.32,-24.61,;30.97,-25.39,;29.63,-24.62,;28.3,-25.39,;26.96,-24.62,;26.96,-23.08,;28.29,-22.31,;28.29,-20.77,;29.63,-23.07,;30.96,-22.28,;33.64,-22.29,;34.98,-23.05,;36.3,-22.27,;36.29,-20.73,;34.93,-19.97,;33.62,-20.76,;37.61,-19.95,;37.58,-18.41,;38.91,-17.62,;40.26,-18.38,;41.58,-17.6,;42.93,-18.36,;42.94,-19.9,;44.25,-17.58,;40.27,-19.92,;38.95,-20.7,)| Show InChI InChI=1S/C21H25N3O4/c1-21(11-27-20-18(28-21)19(22)23-12-24-20)16-8-6-15(7-9-16)14-4-2-13(3-5-14)10-17(25)26/h6-9,12-14H,2-5,10-11H2,1H3,(H,25,26)(H2,22,23,24)/t13-,14-,21?	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	245	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human DGAT1				Bioorg Med Chem Lett 21: 6122-5 (2011) Article DOI: 10.1016/j.bmcl.2011.08.028 BindingDB Entry DOI: 10.7270/Q2MK6D9B
					More data for this Ligand-Target Pair