BDBM50355722 CHEMBL1911157

SMILES: CC(C)Oc1ccc(cc1F)-c1ccc2[C@H](c3ccccc3Oc2n1)C(C)(C)C(=O)Nc1nncs1

InChI Key: InChIKey=JMBHKKUKLYMEPC-QHCPKHFHSA-N

Data: 1 KI  5 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50355722   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50355722 (CHEMBL1911157) Show SMILES CC(C)Oc1ccc(cc1F)-c1ccc2[C@H](c3ccccc3Oc2n1)C(C)(C)C(=O)Nc1nncs1 |r| Show InChI InChI=1S/C27H25FN4O3S/c1-15(2)34-22-12-9-16(13-19(22)28)20-11-10-18-23(17-7-5-6-8-21(17)35-24(18)30-20)27(3,4)25(33)31-26-32-29-14-36-26/h5-15,23H,1-4H3,(H,31,32,33)/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Displacement of GS-red from glucocorticoid receptor by fluorescence polarization assay				J Med Chem 54: 7318-33 (2011) Article DOI: 10.1021/jm200879j BindingDB Entry DOI: 10.7270/Q2W0969M
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50355722 (CHEMBL1911157) Show SMILES CC(C)Oc1ccc(cc1F)-c1ccc2[C@H](c3ccccc3Oc2n1)C(C)(C)C(=O)Nc1nncs1 |r| Show InChI InChI=1S/C27H25FN4O3S/c1-15(2)34-22-12-9-16(13-19(22)28)20-11-10-18-23(17-7-5-6-8-21(17)35-24(18)30-20)27(3,4)25(33)31-26-32-29-14-36-26/h5-15,23H,1-4H3,(H,31,32,33)/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	73	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Transrepression activity at glucocorticoid receptor alpha in IL-1beta-stimulated human A549 cells assessed as inhibition of NFkappaB-dependent E-sele...				J Med Chem 54: 7318-33 (2011) Article DOI: 10.1021/jm200879j BindingDB Entry DOI: 10.7270/Q2W0969M
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50355722 (CHEMBL1911157) Show SMILES CC(C)Oc1ccc(cc1F)-c1ccc2[C@H](c3ccccc3Oc2n1)C(C)(C)C(=O)Nc1nncs1 |r| Show InChI InChI=1S/C27H25FN4O3S/c1-15(2)34-22-12-9-16(13-19(22)28)20-11-10-18-23(17-7-5-6-8-21(17)35-24(18)30-20)27(3,4)25(33)31-26-32-29-14-36-26/h5-15,23H,1-4H3,(H,31,32,33)/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	162	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Transactivation activity at GR-alpha in human NP1 Hela cells assessed as inhibition of GAL4-DBD after 20 hrs by luciferase reporter gene assay				J Med Chem 54: 7318-33 (2011) Article DOI: 10.1021/jm200879j BindingDB Entry DOI: 10.7270/Q2W0969M
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50355722 (CHEMBL1911157) Show SMILES CC(C)Oc1ccc(cc1F)-c1ccc2[C@H](c3ccccc3Oc2n1)C(C)(C)C(=O)Nc1nncs1 |r| Show InChI InChI=1S/C27H25FN4O3S/c1-15(2)34-22-12-9-16(13-19(22)28)20-11-10-18-23(17-7-5-6-8-21(17)35-24(18)30-20)27(3,4)25(33)31-26-32-29-14-36-26/h5-15,23H,1-4H3,(H,31,32,33)/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	47	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Transrepression activity at glucocorticoid receptor alpha in phorbol myristate acetate-stimulated human A549 cells assessed as inhibition of AP1 resp...				J Med Chem 54: 7318-33 (2011) Article DOI: 10.1021/jm200879j BindingDB Entry DOI: 10.7270/Q2W0969M
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50355722 (CHEMBL1911157) Show SMILES CC(C)Oc1ccc(cc1F)-c1ccc2[C@H](c3ccccc3Oc2n1)C(C)(C)C(=O)Nc1nncs1 |r| Show InChI InChI=1S/C27H25FN4O3S/c1-15(2)34-22-12-9-16(13-19(22)28)20-11-10-18-23(17-7-5-6-8-21(17)35-24(18)30-20)27(3,4)25(33)31-26-32-29-14-36-26/h5-15,23H,1-4H3,(H,31,32,33)/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	496	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Transactivation activity at GR-alpha in human NP1 Hela cells assessed as induction of GAL4-DBD after 20 hrs by luciferase reporter gene assay				J Med Chem 54: 7318-33 (2011) Article DOI: 10.1021/jm200879j BindingDB Entry DOI: 10.7270/Q2W0969M
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50355722 (CHEMBL1911157) Show SMILES CC(C)Oc1ccc(cc1F)-c1ccc2[C@H](c3ccccc3Oc2n1)C(C)(C)C(=O)Nc1nncs1 |r| Show InChI InChI=1S/C27H25FN4O3S/c1-15(2)34-22-12-9-16(13-19(22)28)20-11-10-18-23(17-7-5-6-8-21(17)35-24(18)30-20)27(3,4)25(33)31-26-32-29-14-36-26/h5-15,23H,1-4H3,(H,31,32,33)/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	876	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Transactivation activity at glucocorticoid receptor alpha human 13D3/Huh7 cells assessed as induction of TAT activity after 4 hrs by spectrophotometr...				J Med Chem 54: 7318-33 (2011) Article DOI: 10.1021/jm200879j BindingDB Entry DOI: 10.7270/Q2W0969M
					More data for this Ligand-Target Pair