BDBM50355861 CHEMBL1909733

SMILES: Brc1ccccc1-c1c[nH]nn1

InChI Key: InChIKey=FMNFGAAZKHHVAD-UHFFFAOYSA-N

Data: 1 KI  7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50355861   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Indoleamine 2,3-dioxygenase (Homo sapiens (Human))	BDBM50355861 (CHEMBL1909733) Show SMILES Brc1ccccc1-c1c[nH]nn1 Show InChI InChI=1S/C8H6BrN3/c9-7-4-2-1-3-6(7)8-5-10-12-11-8/h1-5H,(H,10,11,12)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Uncompetitive inhibition of human recombinant indoleamine-2,3-dioxygenase expressed in Escherichia coli BL21 using L-tryptophan as substrate by Dixon...				Eur J Med Chem 46: 5680-7 (2011) Article DOI: 10.1016/j.ejmech.2011.08.044 BindingDB Entry DOI: 10.7270/Q2KH0NRS
					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase (Homo sapiens (Human))	BDBM50355861 (CHEMBL1909733) Show SMILES Brc1ccccc1-c1c[nH]nn1 Show InChI InChI=1S/C8H6BrN3/c9-7-4-2-1-3-6(7)8-5-10-12-11-8/h1-5H,(H,10,11,12)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of indoleamine-2,3-dioxygenase in human HEK293 cells assessed as N-formylkynurenine level after 5 hrs by spectrophotometric analysis				Eur J Med Chem 46: 5680-7 (2011) Article DOI: 10.1016/j.ejmech.2011.08.044 BindingDB Entry DOI: 10.7270/Q2KH0NRS
					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase (Homo sapiens (Human))	BDBM50355861 (CHEMBL1909733) Show SMILES Brc1ccccc1-c1c[nH]nn1 Show InChI InChI=1S/C8H6BrN3/c9-7-4-2-1-3-6(7)8-5-10-12-11-8/h1-5H,(H,10,11,12)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.40E+3	n/a	n/a	n/a	n/a	6.5	n/a
Ludwig Center for Cancer Research of the University of Lausanne Curated by ChEMBL					Assay Description Inhibition of human recombinant N-terminal His-tagged IDO1 (Ala2 to Gly403) overexpressed in Escherichia coli BL21 at pH 6.5 after 60 mins by HPLC an...				J Med Chem 55: 5270-90 (2012) Article DOI: 10.1021/jm300260v BindingDB Entry DOI: 10.7270/Q27H1KNW
					More data for this Ligand-Target Pair
Tryptophan 2,3-dioxygenase (Homo sapiens (Human))	BDBM50355861 (CHEMBL1909733) Show SMILES Brc1ccccc1-c1c[nH]nn1 Show InChI InChI=1S/C8H6BrN3/c9-7-4-2-1-3-6(7)8-5-10-12-11-8/h1-5H,(H,10,11,12)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Ludwig Center for Cancer Research of the University of Lausanne Curated by ChEMBL					Assay Description Inhibition of human TDO transfected in mouse P815B clone 19 cells by HPLC analysis				J Med Chem 55: 5270-90 (2012) Article DOI: 10.1021/jm300260v BindingDB Entry DOI: 10.7270/Q27H1KNW
					More data for this Ligand-Target Pair
Tryptophan 2,3-dioxygenase (Mus musculus)	BDBM50355861 (CHEMBL1909733) Show SMILES Brc1ccccc1-c1c[nH]nn1 Show InChI InChI=1S/C8H6BrN3/c9-7-4-2-1-3-6(7)8-5-10-12-11-8/h1-5H,(H,10,11,12)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Ludwig Center for Cancer Research of the University of Lausanne Curated by ChEMBL					Assay Description Inhibition of mouse TDO in P815 clone 12 cells by HPLC analysis				J Med Chem 55: 5270-90 (2012) Article DOI: 10.1021/jm300260v BindingDB Entry DOI: 10.7270/Q27H1KNW
					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Mus musculus)	BDBM50355861 (CHEMBL1909733) Show SMILES Brc1ccccc1-c1c[nH]nn1 Show InChI InChI=1S/C8H6BrN3/c9-7-4-2-1-3-6(7)8-5-10-12-11-8/h1-5H,(H,10,11,12)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Ludwig Center for Cancer Research of the University of Lausanne Curated by ChEMBL					Assay Description Inhibition of mouse IDO1 in P815 clone 6 cells by HPLC analysis				J Med Chem 55: 5270-90 (2012) Article DOI: 10.1021/jm300260v BindingDB Entry DOI: 10.7270/Q27H1KNW
					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase (Homo sapiens (Human))	BDBM50355861 (CHEMBL1909733) Show SMILES Brc1ccccc1-c1c[nH]nn1 Show InChI InChI=1S/C8H6BrN3/c9-7-4-2-1-3-6(7)8-5-10-12-11-8/h1-5H,(H,10,11,12)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.48E+5	n/a	n/a	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of human recombinant indoleamine-2,3-dioxygenase expressed in Escherichia coli BL21 using L-tryptophan as substrate after 30 mins by micro...				Eur J Med Chem 46: 5680-7 (2011) Article DOI: 10.1016/j.ejmech.2011.08.044 BindingDB Entry DOI: 10.7270/Q2KH0NRS
					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase (Homo sapiens (Human))	BDBM50355861 (CHEMBL1909733) Show SMILES Brc1ccccc1-c1c[nH]nn1 Show InChI InChI=1S/C8H6BrN3/c9-7-4-2-1-3-6(7)8-5-10-12-11-8/h1-5H,(H,10,11,12)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Ludwig Center for Cancer Research of the University of Lausanne Curated by ChEMBL					Assay Description Inhibition of human IDO1 transfected in mouse P815B clone-6 cells by HPLC analysis				J Med Chem 55: 5270-90 (2012) Article DOI: 10.1021/jm300260v BindingDB Entry DOI: 10.7270/Q27H1KNW
					More data for this Ligand-Target Pair