BindingDB PrimarySearch

BDBM50356428 CHEMBL1911572

SMILES: CCN(CC)c1ccc(NC(=O)c2cn(Cc3c(F)cccc3Cl)c3ccc(=O)[nH]c3c2=O)cc1

InChI Key: InChIKey=WZRPREYJPXVHGG-UHFFFAOYSA-N

Data: 10 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50356428
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50356428 (CHEMBL1911572) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
biocrea GmbH Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE5A				Bioorg Med Chem Lett 21: 6652-6 (2011) Article DOI: 10.1016/j.bmcl.2011.09.065 BindingDB Entry DOI: 10.7270/Q2KD1Z91
biocrea GmbH Curated by ChEMBL					More data for this Ligand-Target Pair
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (Homo sapiens (Human))	BDBM50356428 (CHEMBL1911572) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
biocrea GmbH Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE11A				Bioorg Med Chem Lett 21: 6652-6 (2011) Article DOI: 10.1016/j.bmcl.2011.09.065 BindingDB Entry DOI: 10.7270/Q2KD1Z91
biocrea GmbH Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM50356428 (CHEMBL1911572) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
biocrea GmbH Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE1B				Bioorg Med Chem Lett 21: 6652-6 (2011) Article DOI: 10.1016/j.bmcl.2011.09.065 BindingDB Entry DOI: 10.7270/Q2KD1Z91
biocrea GmbH Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50356428 (CHEMBL1911572) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
biocrea GmbH Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE2A				Bioorg Med Chem Lett 21: 6652-6 (2011) Article DOI: 10.1016/j.bmcl.2011.09.065 BindingDB Entry DOI: 10.7270/Q2KD1Z91
biocrea GmbH Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM50356428 (CHEMBL1911572) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
biocrea GmbH Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4A4 expressed in baculovirus infected insect Sf21 cells after 30 mins by scintillation proximity assay				Bioorg Med Chem Lett 21: 6652-6 (2011) Article DOI: 10.1016/j.bmcl.2011.09.065 BindingDB Entry DOI: 10.7270/Q2KD1Z91
biocrea GmbH Curated by ChEMBL					More data for this Ligand-Target Pair
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (Homo sapiens (Human))	BDBM50356428 (CHEMBL1911572) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
biocrea GmbH Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE8A				Bioorg Med Chem Lett 21: 6652-6 (2011) Article DOI: 10.1016/j.bmcl.2011.09.065 BindingDB Entry DOI: 10.7270/Q2KD1Z91
biocrea GmbH Curated by ChEMBL					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Homo sapiens (Human))	BDBM50356428 (CHEMBL1911572) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
biocrea GmbH Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE9A				Bioorg Med Chem Lett 21: 6652-6 (2011) Article DOI: 10.1016/j.bmcl.2011.09.065 BindingDB Entry DOI: 10.7270/Q2KD1Z91
biocrea GmbH Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50356428 (CHEMBL1911572) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
biocrea GmbH Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE10A				Bioorg Med Chem Lett 21: 6652-6 (2011) Article DOI: 10.1016/j.bmcl.2011.09.065 BindingDB Entry DOI: 10.7270/Q2KD1Z91
biocrea GmbH Curated by ChEMBL					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50356428 (CHEMBL1911572) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
biocrea GmbH Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE7A1 expressed in baculovirus infected insect Sf21 cells after 30 mins by scintillation proximity assay				Bioorg Med Chem Lett 21: 6652-6 (2011) Article DOI: 10.1016/j.bmcl.2011.09.065 BindingDB Entry DOI: 10.7270/Q2KD1Z91
biocrea GmbH Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase A (Homo sapiens (Human))	BDBM50356428 (CHEMBL1911572) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
biocrea GmbH Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE3A				Bioorg Med Chem Lett 21: 6652-6 (2011) Article DOI: 10.1016/j.bmcl.2011.09.065 BindingDB Entry DOI: 10.7270/Q2KD1Z91
biocrea GmbH Curated by ChEMBL					More data for this Ligand-Target Pair