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BDBM50356465 CHEMBL1911853

SMILES: COc1ccccc1C1=NCC2(CN3CCC2CC3)NC(=O)C1

InChI Key: InChIKey=GYVKBUHJDSHRBT-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50356465   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neuronal acetylcholine receptor subunit alpha-7


(Rattus norvegicus (Rat))		BDBM50356465
PNG
(CHEMBL1911853)
Show SMILES COc1ccccc1C1=NCC2(CN3CCC2CC3)NC(=O)C1 |t:9,(18.3,-3.46,;17.56,-2.11,;18.34,-.8,;19.88,-.82,;20.68,.5,;19.92,1.85,;18.38,1.87,;17.6,.55,;16.07,.57,;15.38,-.82,;13.86,-1.14,;12.67,-.15,;12.67,-1.7,;11.34,-2.46,;10.01,-1.7,;10.01,-.16,;11.34,.62,;12.09,-.71,;10.76,-1.47,;12.7,1.38,;13.92,2.33,;13.6,3.84,;15.42,1.97,)|
Show InChI InChI=1S/C18H23N3O2/c1-23-16-5-3-2-4-14(16)15-10-17(22)20-18(11-19-15)12-21-8-6-13(18)7-9-21/h2-5,13H,6-12H2,1H3,(H,20,22)
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Similars
Article
PubMed
 110n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]-methyllycaconitine from alpha7 nAChR in rat hippocampal membranes after 2 hrs by liquid scintillation counting

Eur J Med Chem 46: 5625-35 (2011)


Article DOI: 10.1016/j.ejmech.2011.09.033
BindingDB Entry DOI: 10.7270/Q2639Q4D
More data for this
Ligand-Target Pair