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BDBM50356467 CHEMBL1911855

SMILES: COc1ccc(cc1)C1=NCC2(CN3CCC2CC3)NC(=O)C1

InChI Key: InChIKey=ILFNKEIOUVWEAX-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50356467   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neuronal acetylcholine receptor subunit alpha-7


(Rattus norvegicus (Rat))		BDBM50356467
PNG
(CHEMBL1911855)
Show SMILES COc1ccc(cc1)C1=NCC2(CN3CCC2CC3)NC(=O)C1 |t:9,(6.56,-10.44,;5.77,-11.76,;4.24,-11.74,;3.45,-13.07,;1.91,-13.04,;1.16,-11.69,;1.95,-10.38,;3.48,-10.39,;-.37,-11.67,;-1.06,-13.06,;-2.57,-13.38,;-3.77,-12.4,;-3.77,-13.94,;-5.1,-14.7,;-6.42,-13.94,;-6.42,-12.4,;-5.1,-11.62,;-4.34,-12.95,;-5.68,-13.71,;-3.74,-10.86,;-2.51,-9.91,;-2.84,-8.4,;-1.01,-10.27,)|
Show InChI InChI=1S/C18H23N3O2/c1-23-15-4-2-13(3-5-15)16-10-17(22)20-18(11-19-16)12-21-8-6-14(18)7-9-21/h2-5,14H,6-12H2,1H3,(H,20,22)
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Article
PubMed
 42n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]-methyllycaconitine from alpha7 nAChR in rat hippocampal membranes after 2 hrs by liquid scintillation counting

Eur J Med Chem 46: 5625-35 (2011)


Article DOI: 10.1016/j.ejmech.2011.09.033
BindingDB Entry DOI: 10.7270/Q2639Q4D
More data for this
Ligand-Target Pair