BDBM50356677 CHEMBL1917592
SMILES: CCCS(=O)(=O)c1ccc(F)c(c1)C#Cc1cc(Cl)ccc1OCC(O)=O
InChI Key: InChIKey=FLVRGQWJTKWGBU-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G protein-coupled receptor 44 (Mus musculus (mouse)) | BDBM50356677 (CHEMBL1917592) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono S.A. Curated by ChEMBL | Assay Description Displacement of [3H]PGD2 from mouse CRTH2 expressed in human HEK cells by liquid scintillation counting | J Med Chem 54: 7299-317 (2011) Article DOI: 10.1021/jm200866y BindingDB Entry DOI: 10.7270/Q2N58MS1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-coupled receptor 44 (Homo sapiens (Human)) | BDBM50356677 (CHEMBL1917592) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono S.A. Curated by ChEMBL | Assay Description Displacement of [3H]PGD2 from human CRTH2 expressed in chinese hamster CHO cells by liquid scintillation counting | J Med Chem 54: 7299-317 (2011) Article DOI: 10.1021/jm200866y BindingDB Entry DOI: 10.7270/Q2N58MS1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-coupled receptor 44 (Homo sapiens (Human)) | BDBM50356677 (CHEMBL1917592) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono S.A. Curated by ChEMBL | Assay Description Antagonist activity human CRTH2 expressed in chinese hamster CHO cells assessed as inhibition of PGD2-induced [35S]GTPgamma binding by liquid scintil... | J Med Chem 54: 7299-317 (2011) Article DOI: 10.1021/jm200866y BindingDB Entry DOI: 10.7270/Q2N58MS1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-coupled receptor 44 (Homo sapiens (Human)) | BDBM50356677 (CHEMBL1917592) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono S.A. Curated by ChEMBL | Assay Description Antagonist activity at human CRTH2 expressed in human CHO cells by cellular dielectric spectroscopy | J Med Chem 54: 7299-317 (2011) Article DOI: 10.1021/jm200866y BindingDB Entry DOI: 10.7270/Q2N58MS1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-coupled receptor 44 (Homo sapiens (Human)) | BDBM50356677 (CHEMBL1917592) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Serono S.A. Curated by ChEMBL | Assay Description Antagonist activity at CRTH2 in human blood cells assessed as inhibition of PGD2-induced eosinophil cell shape change after 10 mins by flow cytometry | J Med Chem 54: 7299-317 (2011) Article DOI: 10.1021/jm200866y BindingDB Entry DOI: 10.7270/Q2N58MS1 | |||||||||||
More data for this Ligand-Target Pair |