BindingDB PrimarySearch

BDBM50356884 CHEMBL1915540

SMILES: CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(N)n1

InChI Key: InChIKey=ISBHYKVAFKTATD-SNVBAGLBSA-N

Data: 12 KI 3 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50356884
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histamine H4 receptor (Homo sapiens (Human))	BDBM50356884 (CHEMBL1915540) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	1.56	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamas...				Bioorg Med Chem Lett 21: 6596-602 (2011) Article DOI: 10.1016/j.bmcl.2011.07.125 BindingDB Entry DOI: 10.7270/Q20C4W6C
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50356884 (CHEMBL1915540) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, LLC Curated by ChEMBL					Assay Description Binding affinity to human histamine H4 receptor				J Med Chem 58: 7119-27 (2015) BindingDB Entry DOI: 10.7270/Q20G3MZK
Janssen Research& Development, LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50356884 (CHEMBL1915540) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cells				Bioorg Med Chem Lett 21: 6596-602 (2011) Article DOI: 10.1016/j.bmcl.2011.07.125 BindingDB Entry DOI: 10.7270/Q20C4W6C
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50356884 (CHEMBL1915540) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	6.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells				J Med Chem 58: 7119-27 (2015) BindingDB Entry DOI: 10.7270/Q20G3MZK
Janssen Research& Development, LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H4 Receptor (Rattus norvegicus (rat))	BDBM50356884 (CHEMBL1915540) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]histamine from rat histamine H4 receptor expressed in HEK293T cells				J Med Chem 58: 7119-27 (2015) BindingDB Entry DOI: 10.7270/Q20G3MZK
Janssen Research& Development, LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H4 Receptor (Rattus norvegicus (rat))	BDBM50356884 (CHEMBL1915540) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	12.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Displacement of [3H]-histamine from rat H4R expressed in HEK293T cells				Bioorg Med Chem Lett 21: 6596-602 (2011) Article DOI: 10.1016/j.bmcl.2011.07.125 BindingDB Entry DOI: 10.7270/Q20C4W6C
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H4 Receptor (Mus musculus (mouse))	BDBM50356884 (CHEMBL1915540) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	20.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Displacement of [3H]-histamine from mouse H4R expressed in HEK293T cells				Bioorg Med Chem Lett 21: 6596-602 (2011) Article DOI: 10.1016/j.bmcl.2011.07.125 BindingDB Entry DOI: 10.7270/Q20C4W6C
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H4 Receptor (Mus musculus (mouse))	BDBM50356884 (CHEMBL1915540) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]histamine from mouse histamine H4 receptor expressed in HEK293T cells				J Med Chem 58: 7119-27 (2015) BindingDB Entry DOI: 10.7270/Q20G3MZK
Janssen Research& Development, LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H4 Receptor (Mus musculus (mouse))	BDBM50356884 (CHEMBL1915540) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	55	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Griffin Discoveries BV Curated by ChEMBL					Assay Description Binding affinity to mouse histamine H4 receptor				Bioorg Med Chem Lett 23: 2663-70 (2013) Article DOI: 10.1016/j.bmcl.2013.02.091 BindingDB Entry DOI: 10.7270/Q2K35W11
Griffin Discoveries BV Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H4 Receptor (Rattus norvegicus (rat))	BDBM50356884 (CHEMBL1915540) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	55	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Griffin Discoveries BV Curated by ChEMBL					Assay Description Binding affinity to rat histamine H4 receptor				Bioorg Med Chem Lett 23: 2663-70 (2013) Article DOI: 10.1016/j.bmcl.2013.02.091 BindingDB Entry DOI: 10.7270/Q2K35W11
Griffin Discoveries BV Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H4 receptor (GUINEA PIG)	BDBM50356884 (CHEMBL1915540) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	123	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]histamine from guinea pig histamine H4 receptor expressed in HEK293T cells				J Med Chem 58: 7119-27 (2015) BindingDB Entry DOI: 10.7270/Q20G3MZK
Janssen Research& Development, LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H4 receptor (GUINEA PIG)	BDBM50356884 (CHEMBL1915540) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	123	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Displacement of [3H]-histamine from guinea pig H4R expressed in HEK293T cells				Bioorg Med Chem Lett 21: 6596-602 (2011) Article DOI: 10.1016/j.bmcl.2011.07.125 BindingDB Entry DOI: 10.7270/Q20C4W6C
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50356884 (CHEMBL1915540) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced CD11b upregulation				Bioorg Med Chem Lett 21: 6596-602 (2011) Article DOI: 10.1016/j.bmcl.2011.07.125 BindingDB Entry DOI: 10.7270/Q20C4W6C
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50356884 (CHEMBL1915540) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.650	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced shape change by GAFS assay				Bioorg Med Chem Lett 21: 6596-602 (2011) Article DOI: 10.1016/j.bmcl.2011.07.125 BindingDB Entry DOI: 10.7270/Q20C4W6C
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50356884 (CHEMBL1915540) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at H4R in human eosinophils assessed as inhibition of histamine-induced actin polymerisation				Bioorg Med Chem Lett 21: 6596-602 (2011) Article DOI: 10.1016/j.bmcl.2011.07.125 BindingDB Entry DOI: 10.7270/Q20C4W6C
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair