BDBM50356887 CHEMBL1915347

SMILES: CN1C[C@H]2CN(C[C@H]2C1)C(=O)c1nc2cc(F)c(F)cc2[nH]1

InChI Key: InChIKey=KWTJQJSBJGKFFU-DTORHVGOSA-N

Data: 5 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50356887   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H4 receptor (Homo sapiens (Human))	BDBM50356887 (CHEMBL1915347) Show SMILES CN1C[C@H]2CN(C[C@H]2C1)C(=O)c1nc2cc(F)c(F)cc2[nH]1 |r| Show InChI InChI=1S/C15H16F2N4O/c1-20-4-8-6-21(7-9(8)5-20)15(22)14-18-12-2-10(16)11(17)3-13(12)19-14/h2-3,8-9H,4-7H2,1H3,(H,18,19)/t8-,9+	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	53	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamas...				Bioorg Med Chem Lett 21: 6596-602 (2011) Article DOI: 10.1016/j.bmcl.2011.07.125 BindingDB Entry DOI: 10.7270/Q20C4W6C
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50356887 (CHEMBL1915347) Show SMILES CN1C[C@H]2CN(C[C@H]2C1)C(=O)c1nc2cc(F)c(F)cc2[nH]1 |r| Show InChI InChI=1S/C15H16F2N4O/c1-20-4-8-6-21(7-9(8)5-20)15(22)14-18-12-2-10(16)11(17)3-13(12)19-14/h2-3,8-9H,4-7H2,1H3,(H,18,19)/t8-,9+	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	128	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cells				Bioorg Med Chem Lett 21: 6596-602 (2011) Article DOI: 10.1016/j.bmcl.2011.07.125 BindingDB Entry DOI: 10.7270/Q20C4W6C
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50356887 (CHEMBL1915347) Show SMILES CN1C[C@H]2CN(C[C@H]2C1)C(=O)c1nc2cc(F)c(F)cc2[nH]1 |r| Show InChI InChI=1S/C15H16F2N4O/c1-20-4-8-6-21(7-9(8)5-20)15(22)14-18-12-2-10(16)11(17)3-13(12)19-14/h2-3,8-9H,4-7H2,1H3,(H,18,19)/t8-,9+	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	128	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding...				Bioorg Med Chem Lett 22: 1156-9 (2012) Article DOI: 10.1016/j.bmcl.2011.11.098 BindingDB Entry DOI: 10.7270/Q2Q81DJD
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50356887 (CHEMBL1915347) Show SMILES CN1C[C@H]2CN(C[C@H]2C1)C(=O)c1nc2cc(F)c(F)cc2[nH]1 |r| Show InChI InChI=1S/C15H16F2N4O/c1-20-4-8-6-21(7-9(8)5-20)15(22)14-18-12-2-10(16)11(17)3-13(12)19-14/h2-3,8-9H,4-7H2,1H3,(H,18,19)/t8-,9+	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	236	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by ...				Bioorg Med Chem Lett 22: 1156-9 (2012) Article DOI: 10.1016/j.bmcl.2011.11.098 BindingDB Entry DOI: 10.7270/Q2Q81DJD
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50356887 (CHEMBL1915347) Show SMILES CN1C[C@H]2CN(C[C@H]2C1)C(=O)c1nc2cc(F)c(F)cc2[nH]1 |r| Show InChI InChI=1S/C15H16F2N4O/c1-20-4-8-6-21(7-9(8)5-20)15(22)14-18-12-2-10(16)11(17)3-13(12)19-14/h2-3,8-9H,4-7H2,1H3,(H,18,19)/t8-,9+	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.79E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to human histamine H3 receptor				Bioorg Med Chem Lett 22: 1156-9 (2012) Article DOI: 10.1016/j.bmcl.2011.11.098 BindingDB Entry DOI: 10.7270/Q2Q81DJD
					More data for this Ligand-Target Pair