BDBM50356982 CHEMBL1916239

SMILES: CC(=O)N[C@H]1C(C)(C)[C@H](Oc2ccc(C#N)c(c2)C(F)(F)F)C1(C)C

InChI Key: InChIKey=URADNFWSEYDNBU-SHTZXODSSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50356982   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Androgen Receptor (Homo sapiens (Human))	BDBM50356982 (CHEMBL1916239) Show SMILES CC(=O)N[C@H]1C(C)(C)[C@H](Oc2ccc(C#N)c(c2)C(F)(F)F)C1(C)C |r,wU:4.3,wD:8.8,(30.13,-7.85,;28.78,-7.11,;27.46,-7.9,;28.75,-5.57,;27.4,-4.82,;25.86,-4.82,;25.45,-6.3,;24.36,-5.21,;25.86,-3.28,;24.53,-2.51,;24.54,-.97,;23.21,-.2,;23.2,1.33,;24.54,2.11,;24.55,3.65,;24.56,5.17,;25.88,1.33,;25.87,-.21,;27.21,2.1,;28.54,1.32,;27.22,3.64,;28.54,2.88,;27.4,-3.28,;27.79,-1.78,;28.88,-3.67,)| Show InChI InChI=1S/C18H21F3N2O2/c1-10(24)23-14-16(2,3)15(17(14,4)5)25-12-7-6-11(9-22)13(8-12)18(19,20)21/h6-8,14-15H,1-5H3,(H,23,24)/t14-,15-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at human AR overexpressed in human LNCAP cells by luciferase reporter gene assay				J Med Chem 54: 7693-704 (2011) Article DOI: 10.1021/jm201059s BindingDB Entry DOI: 10.7270/Q2348KS9
					More data for this Ligand-Target Pair