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BDBM50357248 CHEMBL1916478

SMILES: CCCOCCn1c2cc(nnc2c(NCC(=O)N(C)C)nc1=O)-c1ccc(OC)nc1

InChI Key: InChIKey=CUZPLGMPQHOVMB-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50357248   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50357248
PNG
(CHEMBL1916478)
Show SMILES CCCOCCn1c2cc(nnc2c(NCC(=O)N(C)C)nc1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C21H27N7O4/c1-5-9-32-10-8-28-16-11-15(14-6-7-17(31-4)22-12-14)25-26-19(16)20(24-21(28)30)23-13-18(29)27(2)3/h6-7,11-12H,5,8-10,13H2,1-4H3,(H,23,24,30)
PDB
MMDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.440n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 21: 6348-52 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.106
BindingDB Entry DOI: 10.7270/Q2J67HB0
More data for this
Ligand-Target Pair