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BDBM50357252 CHEMBL1916473

SMILES: COc1ccc(cn1)-c1cc2n(CCOCC(F)(F)F)c(=O)nc(N3CCN(CCO)CC3)c2nn1

InChI Key: InChIKey=JCYNZPANZUHPCY-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50357252   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50357252
PNG
(CHEMBL1916473)
Show SMILES COc1ccc(cn1)-c1cc2n(CCOCC(F)(F)F)c(=O)nc(N3CCN(CCO)CC3)c2nn1
Show InChI InChI=1S/C22H26F3N7O4/c1-35-18-3-2-15(13-26-18)16-12-17-19(29-28-16)20(31-6-4-30(5-7-31)8-10-33)27-21(34)32(17)9-11-36-14-22(23,24)25/h2-3,12-13,33H,4-11,14H2,1H3
PDB
MMDB

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PC cid
PC sid
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Article
PubMed
n/an/a 0.640n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDE5


Bioorg Med Chem Lett 21: 6348-52 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.106
BindingDB Entry DOI: 10.7270/Q2J67HB0
More data for this
Ligand-Target Pair