BDBM50357454 CHEMBL1917878
SMILES: O=C(N[C@@H]1c2ccccc2-c2c1cccc2-c1nc2ccncc2[nH]1)c1ccnc2[nH]ccc12
InChI Key: InChIKey=UIRMQSUQFQMQHL-XMMPIXPASA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM50357454 (CHEMBL1917878) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-Aventis Research and Development Curated by ChEMBL | Assay Description Inhibition of HSP90beta in human SKBR3 cells assessed as down regulation of HER2 expression levels after 24 hrs by FACS analysis | J Med Chem 54: 7206-19 (2011) Article DOI: 10.1021/jm200784m BindingDB Entry DOI: 10.7270/Q2QR4XH4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Heat shock protein HSP 90-beta (Homo sapiens (Human)) | BDBM50357454 (CHEMBL1917878) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 0.350 | n/a | n/a | n/a | n/a | n/a |
Sanofi-Aventis Research and Development Curated by ChEMBL | Assay Description Binding affinity to human Hsp90beta after overnight incubation by fluorescence polarization assay | J Med Chem 54: 7206-19 (2011) Article DOI: 10.1021/jm200784m BindingDB Entry DOI: 10.7270/Q2QR4XH4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |