Found 11 hits for monomerid = 50357820 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50357820
(CHEMBL1915910)Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4c(C)nn(C)c4C)n3c2n1 |(6.95,-22.59,;8.28,-23.36,;9.62,-22.59,;9.62,-21.05,;10.95,-20.28,;12.28,-21.04,;13.62,-20.25,;14.97,-21.03,;16.3,-20.25,;14.98,-22.58,;16.13,-23.63,;17.64,-23.31,;15.5,-25.05,;13.95,-24.89,;13.06,-26.14,;13.54,-27.6,;15.01,-28.07,;12.31,-28.52,;11.05,-27.62,;9.59,-28.11,;11.52,-26.15,;10.6,-24.92,;13.63,-23.36,;12.29,-22.59,;10.95,-23.36,)| Show InChI InChI=1S/C18H20N6O/c1-9-15(12(4)23(5)22-9)18-20-11(3)16-10(2)19-13-7-8-14(25-6)21-17(13)24(16)18/h7-8H,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE5A using [3H]cGMP after 1 hr by scintillation proximity assay |
J Med Chem 54: 7621-38 (2011)
Article DOI: 10.1021/jm2009138
BindingDB Entry DOI: 10.7270/Q2125T2B |
More data for this
Ligand-Target Pair | |
Phosphodiesterase 11A (PDE11A)
(Homo sapiens (Human)) | BDBM50357820
(CHEMBL1915910)Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4c(C)nn(C)c4C)n3c2n1 |(6.95,-22.59,;8.28,-23.36,;9.62,-22.59,;9.62,-21.05,;10.95,-20.28,;12.28,-21.04,;13.62,-20.25,;14.97,-21.03,;16.3,-20.25,;14.98,-22.58,;16.13,-23.63,;17.64,-23.31,;15.5,-25.05,;13.95,-24.89,;13.06,-26.14,;13.54,-27.6,;15.01,-28.07,;12.31,-28.52,;11.05,-27.62,;9.59,-28.11,;11.52,-26.15,;10.6,-24.92,;13.63,-23.36,;12.29,-22.59,;10.95,-23.36,)| Show InChI InChI=1S/C18H20N6O/c1-9-15(12(4)23(5)22-9)18-20-11(3)16-10(2)19-13-7-8-14(25-6)21-17(13)24(16)18/h7-8H,1-6H3 | KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE11A using [3H]cAMP after 1 hr by scintillation proximity assay |
J Med Chem 54: 7621-38 (2011)
Article DOI: 10.1021/jm2009138
BindingDB Entry DOI: 10.7270/Q2125T2B |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50357820
(CHEMBL1915910)Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4c(C)nn(C)c4C)n3c2n1 |(6.95,-22.59,;8.28,-23.36,;9.62,-22.59,;9.62,-21.05,;10.95,-20.28,;12.28,-21.04,;13.62,-20.25,;14.97,-21.03,;16.3,-20.25,;14.98,-22.58,;16.13,-23.63,;17.64,-23.31,;15.5,-25.05,;13.95,-24.89,;13.06,-26.14,;13.54,-27.6,;15.01,-28.07,;12.31,-28.52,;11.05,-27.62,;9.59,-28.11,;11.52,-26.15,;10.6,-24.92,;13.63,-23.36,;12.29,-22.59,;10.95,-23.36,)| Show InChI InChI=1S/C18H20N6O/c1-9-15(12(4)23(5)22-9)18-20-11(3)16-10(2)19-13-7-8-14(25-6)21-17(13)24(16)18/h7-8H,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay |
J Med Chem 54: 7621-38 (2011)
Article DOI: 10.1021/jm2009138
BindingDB Entry DOI: 10.7270/Q2125T2B |
More data for this
Ligand-Target Pair | |
Phosphodiesterase 3 (PDE3)
(Homo sapiens (Human)) | BDBM50357820
(CHEMBL1915910)Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4c(C)nn(C)c4C)n3c2n1 |(6.95,-22.59,;8.28,-23.36,;9.62,-22.59,;9.62,-21.05,;10.95,-20.28,;12.28,-21.04,;13.62,-20.25,;14.97,-21.03,;16.3,-20.25,;14.98,-22.58,;16.13,-23.63,;17.64,-23.31,;15.5,-25.05,;13.95,-24.89,;13.06,-26.14,;13.54,-27.6,;15.01,-28.07,;12.31,-28.52,;11.05,-27.62,;9.59,-28.11,;11.52,-26.15,;10.6,-24.92,;13.63,-23.36,;12.29,-22.59,;10.95,-23.36,)| Show InChI InChI=1S/C18H20N6O/c1-9-15(12(4)23(5)22-9)18-20-11(3)16-10(2)19-13-7-8-14(25-6)21-17(13)24(16)18/h7-8H,1-6H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE3A using [3H]cAMP after 1 hr by scintillation proximity assay |
J Med Chem 54: 7621-38 (2011)
Article DOI: 10.1021/jm2009138
BindingDB Entry DOI: 10.7270/Q2125T2B |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50357820
(CHEMBL1915910)Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4c(C)nn(C)c4C)n3c2n1 |(6.95,-22.59,;8.28,-23.36,;9.62,-22.59,;9.62,-21.05,;10.95,-20.28,;12.28,-21.04,;13.62,-20.25,;14.97,-21.03,;16.3,-20.25,;14.98,-22.58,;16.13,-23.63,;17.64,-23.31,;15.5,-25.05,;13.95,-24.89,;13.06,-26.14,;13.54,-27.6,;15.01,-28.07,;12.31,-28.52,;11.05,-27.62,;9.59,-28.11,;11.52,-26.15,;10.6,-24.92,;13.63,-23.36,;12.29,-22.59,;10.95,-23.36,)| Show InChI InChI=1S/C18H20N6O/c1-9-15(12(4)23(5)22-9)18-20-11(3)16-10(2)19-13-7-8-14(25-6)21-17(13)24(16)18/h7-8H,1-6H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE4A using [3H]cAMP after 1 hr by scintillation proximity assay |
J Med Chem 54: 7621-38 (2011)
Article DOI: 10.1021/jm2009138
BindingDB Entry DOI: 10.7270/Q2125T2B |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
(Homo sapiens (Human)) | BDBM50357820
(CHEMBL1915910)Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4c(C)nn(C)c4C)n3c2n1 |(6.95,-22.59,;8.28,-23.36,;9.62,-22.59,;9.62,-21.05,;10.95,-20.28,;12.28,-21.04,;13.62,-20.25,;14.97,-21.03,;16.3,-20.25,;14.98,-22.58,;16.13,-23.63,;17.64,-23.31,;15.5,-25.05,;13.95,-24.89,;13.06,-26.14,;13.54,-27.6,;15.01,-28.07,;12.31,-28.52,;11.05,-27.62,;9.59,-28.11,;11.52,-26.15,;10.6,-24.92,;13.63,-23.36,;12.29,-22.59,;10.95,-23.36,)| Show InChI InChI=1S/C18H20N6O/c1-9-15(12(4)23(5)22-9)18-20-11(3)16-10(2)19-13-7-8-14(25-6)21-17(13)24(16)18/h7-8H,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE1B using [3H]cAMP after 1 hr by scintillation proximity assay |
J Med Chem 54: 7621-38 (2011)
Article DOI: 10.1021/jm2009138
BindingDB Entry DOI: 10.7270/Q2125T2B |
More data for this
Ligand-Target Pair | |
Phosphodiesterase 7
(Homo sapiens (Human)) | BDBM50357820
(CHEMBL1915910)Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4c(C)nn(C)c4C)n3c2n1 |(6.95,-22.59,;8.28,-23.36,;9.62,-22.59,;9.62,-21.05,;10.95,-20.28,;12.28,-21.04,;13.62,-20.25,;14.97,-21.03,;16.3,-20.25,;14.98,-22.58,;16.13,-23.63,;17.64,-23.31,;15.5,-25.05,;13.95,-24.89,;13.06,-26.14,;13.54,-27.6,;15.01,-28.07,;12.31,-28.52,;11.05,-27.62,;9.59,-28.11,;11.52,-26.15,;10.6,-24.92,;13.63,-23.36,;12.29,-22.59,;10.95,-23.36,)| Show InChI InChI=1S/C18H20N6O/c1-9-15(12(4)23(5)22-9)18-20-11(3)16-10(2)19-13-7-8-14(25-6)21-17(13)24(16)18/h7-8H,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE7A using [3H]cAMP after 1 hr by scintillation proximity assay |
J Med Chem 54: 7621-38 (2011)
Article DOI: 10.1021/jm2009138
BindingDB Entry DOI: 10.7270/Q2125T2B |
More data for this
Ligand-Target Pair | |
Homo sapiens phosphodiesterase 2A (PDE2A)
(Homo sapiens (Human)) | BDBM50357820
(CHEMBL1915910)Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4c(C)nn(C)c4C)n3c2n1 |(6.95,-22.59,;8.28,-23.36,;9.62,-22.59,;9.62,-21.05,;10.95,-20.28,;12.28,-21.04,;13.62,-20.25,;14.97,-21.03,;16.3,-20.25,;14.98,-22.58,;16.13,-23.63,;17.64,-23.31,;15.5,-25.05,;13.95,-24.89,;13.06,-26.14,;13.54,-27.6,;15.01,-28.07,;12.31,-28.52,;11.05,-27.62,;9.59,-28.11,;11.52,-26.15,;10.6,-24.92,;13.63,-23.36,;12.29,-22.59,;10.95,-23.36,)| Show InChI InChI=1S/C18H20N6O/c1-9-15(12(4)23(5)22-9)18-20-11(3)16-10(2)19-13-7-8-14(25-6)21-17(13)24(16)18/h7-8H,1-6H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE2A using [3H]cAMP after 1 hr by scintillation proximity assay |
J Med Chem 54: 7621-38 (2011)
Article DOI: 10.1021/jm2009138
BindingDB Entry DOI: 10.7270/Q2125T2B |
More data for this
Ligand-Target Pair | |
Phosphodiesterase 8
(Homo sapiens (Human)) | BDBM50357820
(CHEMBL1915910)Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4c(C)nn(C)c4C)n3c2n1 |(6.95,-22.59,;8.28,-23.36,;9.62,-22.59,;9.62,-21.05,;10.95,-20.28,;12.28,-21.04,;13.62,-20.25,;14.97,-21.03,;16.3,-20.25,;14.98,-22.58,;16.13,-23.63,;17.64,-23.31,;15.5,-25.05,;13.95,-24.89,;13.06,-26.14,;13.54,-27.6,;15.01,-28.07,;12.31,-28.52,;11.05,-27.62,;9.59,-28.11,;11.52,-26.15,;10.6,-24.92,;13.63,-23.36,;12.29,-22.59,;10.95,-23.36,)| Show InChI InChI=1S/C18H20N6O/c1-9-15(12(4)23(5)22-9)18-20-11(3)16-10(2)19-13-7-8-14(25-6)21-17(13)24(16)18/h7-8H,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay |
J Med Chem 54: 7621-38 (2011)
Article DOI: 10.1021/jm2009138
BindingDB Entry DOI: 10.7270/Q2125T2B |
More data for this
Ligand-Target Pair | |
Phosphodiesterase 9A
(Homo sapiens (Human)) | BDBM50357820
(CHEMBL1915910)Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4c(C)nn(C)c4C)n3c2n1 |(6.95,-22.59,;8.28,-23.36,;9.62,-22.59,;9.62,-21.05,;10.95,-20.28,;12.28,-21.04,;13.62,-20.25,;14.97,-21.03,;16.3,-20.25,;14.98,-22.58,;16.13,-23.63,;17.64,-23.31,;15.5,-25.05,;13.95,-24.89,;13.06,-26.14,;13.54,-27.6,;15.01,-28.07,;12.31,-28.52,;11.05,-27.62,;9.59,-28.11,;11.52,-26.15,;10.6,-24.92,;13.63,-23.36,;12.29,-22.59,;10.95,-23.36,)| Show InChI InChI=1S/C18H20N6O/c1-9-15(12(4)23(5)22-9)18-20-11(3)16-10(2)19-13-7-8-14(25-6)21-17(13)24(16)18/h7-8H,1-6H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PDE9A using [3H]cGMP after 1 hr by scintillation proximity assay |
J Med Chem 54: 7621-38 (2011)
Article DOI: 10.1021/jm2009138
BindingDB Entry DOI: 10.7270/Q2125T2B |
More data for this
Ligand-Target Pair | |
Phosphodiesterase 6
(Bos taurus (Bovine)) | BDBM50357820
(CHEMBL1915910)Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4c(C)nn(C)c4C)n3c2n1 |(6.95,-22.59,;8.28,-23.36,;9.62,-22.59,;9.62,-21.05,;10.95,-20.28,;12.28,-21.04,;13.62,-20.25,;14.97,-21.03,;16.3,-20.25,;14.98,-22.58,;16.13,-23.63,;17.64,-23.31,;15.5,-25.05,;13.95,-24.89,;13.06,-26.14,;13.54,-27.6,;15.01,-28.07,;12.31,-28.52,;11.05,-27.62,;9.59,-28.11,;11.52,-26.15,;10.6,-24.92,;13.63,-23.36,;12.29,-22.59,;10.95,-23.36,)| Show InChI InChI=1S/C18H20N6O/c1-9-15(12(4)23(5)22-9)18-20-11(3)16-10(2)19-13-7-8-14(25-6)21-17(13)24(16)18/h7-8H,1-6H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant bovine PDE6A using [3H]cGMP after 1 hr by scintillation proximity assay |
J Med Chem 54: 7621-38 (2011)
Article DOI: 10.1021/jm2009138
BindingDB Entry DOI: 10.7270/Q2125T2B |
More data for this
Ligand-Target Pair | |
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