BDBM50357822 CHEMBL1915888

SMILES: COc1ccc2nc(C)c3c(C)nc(-c4ccccc4C)n3c2n1

InChI Key: InChIKey=MVPONTPZYKDJPY-UHFFFAOYSA-N

Data: 11 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50357822   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 11A (PDE11A) (Homo sapiens (Human))	BDBM50357822 (CHEMBL1915888) Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccccc4C)n3c2n1 Show InChI InChI=1S/C19H18N4O/c1-11-7-5-6-8-14(11)18-21-13(3)17-12(2)20-15-9-10-16(24-4)22-19(15)23(17)18/h5-10H,1-4H3	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE11A using [3H]cAMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50357822 (CHEMBL1915888) Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccccc4C)n3c2n1 Show InChI InChI=1S/C19H18N4O/c1-11-7-5-6-8-14(11)18-21-13(3)17-12(2)20-15-9-10-16(24-4)22-19(15)23(17)18/h5-10H,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE5A using [3H]cGMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50357822 (CHEMBL1915888) Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccccc4C)n3c2n1 Show InChI InChI=1S/C19H18N4O/c1-11-7-5-6-8-14(11)18-21-13(3)17-12(2)20-15-9-10-16(24-4)22-19(15)23(17)18/h5-10H,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.40	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM50357822 (CHEMBL1915888) Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccccc4C)n3c2n1 Show InChI InChI=1S/C19H18N4O/c1-11-7-5-6-8-14(11)18-21-13(3)17-12(2)20-15-9-10-16(24-4)22-19(15)23(17)18/h5-10H,1-4H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4A using [3H]cAMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair
Phosphodiesterase 6 (Bos taurus (Bovine))	BDBM50357822 (CHEMBL1915888) Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccccc4C)n3c2n1 Show InChI InChI=1S/C19H18N4O/c1-11-7-5-6-8-14(11)18-21-13(3)17-12(2)20-15-9-10-16(24-4)22-19(15)23(17)18/h5-10H,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant bovine PDE6A using [3H]cGMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM50357822 (CHEMBL1915888) Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccccc4C)n3c2n1 Show InChI InChI=1S/C19H18N4O/c1-11-7-5-6-8-14(11)18-21-13(3)17-12(2)20-15-9-10-16(24-4)22-19(15)23(17)18/h5-10H,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE1B using [3H]cAMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM50357822 (CHEMBL1915888) Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccccc4C)n3c2n1 Show InChI InChI=1S/C19H18N4O/c1-11-7-5-6-8-14(11)18-21-13(3)17-12(2)20-15-9-10-16(24-4)22-19(15)23(17)18/h5-10H,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE2A using [3H]cAMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair
Phosphodiesterase 3 (PDE3) (Homo sapiens (Human))	BDBM50357822 (CHEMBL1915888) Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccccc4C)n3c2n1 Show InChI InChI=1S/C19H18N4O/c1-11-7-5-6-8-14(11)18-21-13(3)17-12(2)20-15-9-10-16(24-4)22-19(15)23(17)18/h5-10H,1-4H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE3A using [3H]cAMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair
Phosphodiesterase 8 (Homo sapiens (Human))	BDBM50357822 (CHEMBL1915888) Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccccc4C)n3c2n1 Show InChI InChI=1S/C19H18N4O/c1-11-7-5-6-8-14(11)18-21-13(3)17-12(2)20-15-9-10-16(24-4)22-19(15)23(17)18/h5-10H,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair
Phosphodiesterase 9A (Homo sapiens (Human))	BDBM50357822 (CHEMBL1915888) Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccccc4C)n3c2n1 Show InChI InChI=1S/C19H18N4O/c1-11-7-5-6-8-14(11)18-21-13(3)17-12(2)20-15-9-10-16(24-4)22-19(15)23(17)18/h5-10H,1-4H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE9A using [3H]cGMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair
Phosphodiesterase 7 (Homo sapiens (Human))	BDBM50357822 (CHEMBL1915888) Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccccc4C)n3c2n1 Show InChI InChI=1S/C19H18N4O/c1-11-7-5-6-8-14(11)18-21-13(3)17-12(2)20-15-9-10-16(24-4)22-19(15)23(17)18/h5-10H,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	542	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE7A using [3H]cAMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair