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BDBM50357826 CHEMBL1915892

SMILES: COc1ccc2nc(C)c3c(C)nc(-c4ccc(F)cc4Cl)n3c2n1

InChI Key: InChIKey=FOCSRCJRUICCOO-UHFFFAOYSA-N

Data: 11 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50357826   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50357826
PNG
(CHEMBL1915892)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccc(F)cc4Cl)n3c2n1
Show InChI InChI=1S/C18H14ClFN4O/c1-9-16-10(2)22-17(12-5-4-11(20)8-13(12)19)24(16)18-14(21-9)6-7-15(23-18)25-3/h4-8H,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE5A using [3H]cGMP after 1 hr by scintillation proximity assay

J Med Chem 54: 7621-38 (2011)


Article DOI: 10.1021/jm2009138
BindingDB Entry DOI: 10.7270/Q2125T2B
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))		BDBM50357826
PNG
(CHEMBL1915892)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccc(F)cc4Cl)n3c2n1
Show InChI InChI=1S/C18H14ClFN4O/c1-9-16-10(2)22-17(12-5-4-11(20)8-13(12)19)24(16)18-14(21-9)6-7-15(23-18)25-3/h4-8H,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE11A using [3H]cAMP after 1 hr by scintillation proximity assay

J Med Chem 54: 7621-38 (2011)


Article DOI: 10.1021/jm2009138
BindingDB Entry DOI: 10.7270/Q2125T2B
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50357826
PNG
(CHEMBL1915892)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccc(F)cc4Cl)n3c2n1
Show InChI InChI=1S/C18H14ClFN4O/c1-9-16-10(2)22-17(12-5-4-11(20)8-13(12)19)24(16)18-14(21-9)6-7-15(23-18)25-3/h4-8H,1-3H3
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n/an/a 4.30n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay

J Med Chem 54: 7621-38 (2011)


Article DOI: 10.1021/jm2009138
BindingDB Entry DOI: 10.7270/Q2125T2B
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (Human))		BDBM50357826
PNG
(CHEMBL1915892)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccc(F)cc4Cl)n3c2n1
Show InChI InChI=1S/C18H14ClFN4O/c1-9-16-10(2)22-17(12-5-4-11(20)8-13(12)19)24(16)18-14(21-9)6-7-15(23-18)25-3/h4-8H,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE3A using [3H]cAMP after 1 hr by scintillation proximity assay

J Med Chem 54: 7621-38 (2011)


Article DOI: 10.1021/jm2009138
BindingDB Entry DOI: 10.7270/Q2125T2B
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))		BDBM50357826
PNG
(CHEMBL1915892)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccc(F)cc4Cl)n3c2n1
Show InChI InChI=1S/C18H14ClFN4O/c1-9-16-10(2)22-17(12-5-4-11(20)8-13(12)19)24(16)18-14(21-9)6-7-15(23-18)25-3/h4-8H,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE4A using [3H]cAMP after 1 hr by scintillation proximity assay

J Med Chem 54: 7621-38 (2011)


Article DOI: 10.1021/jm2009138
BindingDB Entry DOI: 10.7270/Q2125T2B
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))		BDBM50357826
PNG
(CHEMBL1915892)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccc(F)cc4Cl)n3c2n1
Show InChI InChI=1S/C18H14ClFN4O/c1-9-16-10(2)22-17(12-5-4-11(20)8-13(12)19)24(16)18-14(21-9)6-7-15(23-18)25-3/h4-8H,1-3H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE7A using [3H]cAMP after 1 hr by scintillation proximity assay

J Med Chem 54: 7621-38 (2011)


Article DOI: 10.1021/jm2009138
BindingDB Entry DOI: 10.7270/Q2125T2B
More data for this
Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A)


(Homo sapiens (Human))		BDBM50357826
PNG
(CHEMBL1915892)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccc(F)cc4Cl)n3c2n1
Show InChI InChI=1S/C18H14ClFN4O/c1-9-16-10(2)22-17(12-5-4-11(20)8-13(12)19)24(16)18-14(21-9)6-7-15(23-18)25-3/h4-8H,1-3H3
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n/an/a 28n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE2A using [3H]cAMP after 1 hr by scintillation proximity assay

J Med Chem 54: 7621-38 (2011)


Article DOI: 10.1021/jm2009138
BindingDB Entry DOI: 10.7270/Q2125T2B
More data for this
Ligand-Target Pair
Phosphodiesterase 8


(Homo sapiens (Human))		BDBM50357826
PNG
(CHEMBL1915892)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccc(F)cc4Cl)n3c2n1
Show InChI InChI=1S/C18H14ClFN4O/c1-9-16-10(2)22-17(12-5-4-11(20)8-13(12)19)24(16)18-14(21-9)6-7-15(23-18)25-3/h4-8H,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assay

J Med Chem 54: 7621-38 (2011)


Article DOI: 10.1021/jm2009138
BindingDB Entry DOI: 10.7270/Q2125T2B
More data for this
Ligand-Target Pair
Phosphodiesterase 9A


(Homo sapiens (Human))		BDBM50357826
PNG
(CHEMBL1915892)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccc(F)cc4Cl)n3c2n1
Show InChI InChI=1S/C18H14ClFN4O/c1-9-16-10(2)22-17(12-5-4-11(20)8-13(12)19)24(16)18-14(21-9)6-7-15(23-18)25-3/h4-8H,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE9A using [3H]cGMP after 1 hr by scintillation proximity assay

J Med Chem 54: 7621-38 (2011)


Article DOI: 10.1021/jm2009138
BindingDB Entry DOI: 10.7270/Q2125T2B
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B


(Homo sapiens (Human))		BDBM50357826
PNG
(CHEMBL1915892)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccc(F)cc4Cl)n3c2n1
Show InChI InChI=1S/C18H14ClFN4O/c1-9-16-10(2)22-17(12-5-4-11(20)8-13(12)19)24(16)18-14(21-9)6-7-15(23-18)25-3/h4-8H,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PDE1B using [3H]cAMP after 1 hr by scintillation proximity assay

J Med Chem 54: 7621-38 (2011)


Article DOI: 10.1021/jm2009138
BindingDB Entry DOI: 10.7270/Q2125T2B
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Bos taurus (Bovine))		BDBM50357826
PNG
(CHEMBL1915892)
Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccc(F)cc4Cl)n3c2n1
Show InChI InChI=1S/C18H14ClFN4O/c1-9-16-10(2)22-17(12-5-4-11(20)8-13(12)19)24(16)18-14(21-9)6-7-15(23-18)25-3/h4-8H,1-3H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant bovine PDE6A using [3H]cGMP after 1 hr by scintillation proximity assay

J Med Chem 54: 7621-38 (2011)


Article DOI: 10.1021/jm2009138
BindingDB Entry DOI: 10.7270/Q2125T2B
More data for this
Ligand-Target Pair