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SMILES: COc1ccc2nc(C)c3c(C)nc(-c4ccncc4Cl)n3c2n1

InChI Key: InChIKey=CWJZCMLRNFECBA-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50357836   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50357836 (CHEMBL1916095) Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccncc4Cl)n3c2n1 Show InChI InChI=1S/C17H14ClN5O/c1-9-15-10(2)21-16(11-6-7-19-8-12(11)18)23(15)17-13(20-9)4-5-14(22-17)24-3/h4-8H,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE2A using [3H]cAMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50357836 (CHEMBL1916095) Show SMILES COc1ccc2nc(C)c3c(C)nc(-c4ccncc4Cl)n3c2n1 Show InChI InChI=1S/C17H14ClN5O/c1-9-15-10(2)21-16(11-6-7-19-8-12(11)18)23(15)17-13(20-9)4-5-14(22-17)24-3/h4-8H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair