BDBM50357878 CHEMBL1916138

SMILES: Cc1nc(-c2ccncc2C)n2c1c(C)nc1c(F)cc(OCC3CC3)cc21

InChI Key: InChIKey=GEVPWAZNJXIORL-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50357878   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50357878 (CHEMBL1916138) Show SMILES Cc1nc(-c2ccncc2C)n2c1c(C)nc1c(F)cc(OCC3CC3)cc21 Show InChI InChI=1S/C22H21FN4O/c1-12-10-24-7-6-17(12)22-26-14(3)21-13(2)25-20-18(23)8-16(9-19(20)27(21)22)28-11-15-4-5-15/h6-10,15H,4-5,11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM50357878 (CHEMBL1916138) Show SMILES Cc1nc(-c2ccncc2C)n2c1c(C)nc1c(F)cc(OCC3CC3)cc21 Show InChI InChI=1S/C22H21FN4O/c1-12-10-24-7-6-17(12)22-26-14(3)21-13(2)25-20-18(23)8-16(9-19(20)27(21)22)28-11-15-4-5-15/h6-10,15H,4-5,11H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE2A using [3H]cAMP after 1 hr by scintillation proximity assay				J Med Chem 54: 7621-38 (2011) Article DOI: 10.1021/jm2009138 BindingDB Entry DOI: 10.7270/Q2125T2B
					More data for this Ligand-Target Pair