BDBM50357907 CHEMBL1916521

SMILES: [O-][n+]1ccc2c(cc(nc2c1-c1c(Cl)cccc1Cl)-c1ccncc1)-c1ccc(F)cc1Cl

InChI Key: InChIKey=PKWSUONXLQXQPH-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50357907   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50357907 (CHEMBL1916521) Show SMILES [O-][n+]1ccc2c(cc(nc2c1-c1c(Cl)cccc1Cl)-c1ccncc1)-c1ccc(F)cc1Cl |(7.36,-4.61,;8.69,-3.84,;8.7,-2.3,;10.03,-1.52,;11.36,-2.29,;12.7,-1.51,;14.04,-2.29,;14.03,-3.84,;12.69,-4.61,;11.36,-3.84,;10.03,-4.61,;10.03,-6.14,;8.7,-6.92,;7.36,-6.15,;8.7,-8.46,;10.04,-9.23,;11.37,-8.44,;11.37,-6.91,;12.7,-6.13,;15.36,-4.61,;15.36,-6.15,;16.69,-6.92,;18.03,-6.16,;18.03,-4.61,;16.69,-3.84,;12.7,.02,;14.03,.79,;14.03,2.33,;12.7,3.1,;12.7,4.64,;11.36,2.32,;11.37,.79,;10.03,.01,)| Show InChI InChI=1S/C25H13Cl3FN3O/c26-19-2-1-3-20(27)23(19)25-24-17(8-11-32(25)33)18(16-5-4-15(29)12-21(16)28)13-22(31-24)14-6-9-30-10-7-14/h1-13H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of human p38alpha MAP kinase after 1 hr by FRET analysis				J Med Chem 54: 7899-910 (2011) Article DOI: 10.1021/jm200975u BindingDB Entry DOI: 10.7270/Q2MW2HKR
					More data for this Ligand-Target Pair