BDBM50358042 CHEMBL1917921

SMILES: FC(F)(F)c1cc(NC(=O)Nc2cccc(c2)C2=Nc3cnn(Cc4ccccc4)c3NC(=O)C2)ccc1Cl

InChI Key: InChIKey=XESCVSLKUVTEOR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50358042   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50358042 (CHEMBL1917921) Show SMILES FC(F)(F)c1cc(NC(=O)Nc2cccc(c2)C2=Nc3cnn(Cc4ccccc4)c3NC(=O)C2)ccc1Cl |t:18| Show InChI InChI=1S/C27H20ClF3N6O2/c28-21-10-9-19(12-20(21)27(29,30)31)34-26(39)33-18-8-4-7-17(11-18)22-13-24(38)36-25-23(35-22)14-32-37(25)15-16-5-2-1-3-6-16/h1-12,14H,13,15H2,(H,36,38)(H2,33,34,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	668	n/a	n/a	n/a	n/a	n/a	n/a
Hanyang University Curated by ChEMBL					Assay Description Inhibition of human CRAF using [gamma-33P]ATP after 40 mins by scintillation counting				Bioorg Med Chem 19: 6760-7 (2011) Article DOI: 10.1016/j.bmc.2011.09.042 BindingDB Entry DOI: 10.7270/Q2G44QPH
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