Found 3 hits for monomerid = 50358241 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cyclin-H/Cyclin-dependent kinase 7
(Homo sapiens (Human)) | BDBM50358241
(CHEMBL1922216)Show SMILES CC[C@H](Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1)C(O)C(C)(C)C |r| Show InChI InChI=1S/C23H34N6O/c1-7-17(19(30)23(4,5)6)26-22-27-20(24-13-16-11-9-8-10-12-16)18-21(28-22)29(14-25-18)15(2)3/h8-12,14-15,17,19,30H,7,13H2,1-6H3,(H2,24,26,27,28)/t17-,19?/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description Inhibition of CDK7/cyclin H |
Bioorg Med Chem 19: 6949-65 (2011)
Article DOI: 10.1016/j.bmc.2011.08.051 BindingDB Entry DOI: 10.7270/Q2NP24V1 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
(Homo sapiens (Human)) | BDBM50358241
(CHEMBL1922216)Show SMILES CC[C@H](Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1)C(O)C(C)(C)C |r| Show InChI InChI=1S/C23H34N6O/c1-7-17(19(30)23(4,5)6)26-22-27-20(24-13-16-11-9-8-10-12-16)18-21(28-22)29(14-25-18)15(2)3/h8-12,14-15,17,19,30H,7,13H2,1-6H3,(H2,24,26,27,28)/t17-,19?/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description Inhibition of CDK1/cyclin B |
Bioorg Med Chem 19: 6949-65 (2011)
Article DOI: 10.1016/j.bmc.2011.08.051 BindingDB Entry DOI: 10.7270/Q2NP24V1 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50358241
(CHEMBL1922216)Show SMILES CC[C@H](Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1)C(O)C(C)(C)C |r| Show InChI InChI=1S/C23H34N6O/c1-7-17(19(30)23(4,5)6)26-22-27-20(24-13-16-11-9-8-10-12-16)18-21(28-22)29(14-25-18)15(2)3/h8-12,14-15,17,19,30H,7,13H2,1-6H3,(H2,24,26,27,28)/t17-,19?/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description Inhibition of ERK2 |
Bioorg Med Chem 19: 6949-65 (2011)
Article DOI: 10.1016/j.bmc.2011.08.051 BindingDB Entry DOI: 10.7270/Q2NP24V1 |
More data for this Ligand-Target Pair | |