BDBM50358333 CHEMBL1922682

SMILES: FC(F)(F)c1oc(cc1C(=O)Nc1ccc(nc1)N1CCOCC1)-c1ccccc1

InChI Key: InChIKey=WIHHZGFYJRFSHB-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50358333   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human))	BDBM50358333 (CHEMBL1922682) Show SMILES FC(F)(F)c1oc(cc1C(=O)Nc1ccc(nc1)N1CCOCC1)-c1ccccc1 Show InChI InChI=1S/C21H18F3N3O3/c22-21(23,24)19-16(12-17(30-19)14-4-2-1-3-5-14)20(28)26-15-6-7-18(25-13-15)27-8-10-29-11-9-27/h1-7,12-13H,8-11H2,(H,26,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	490	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human DGAT1 expressed in CHOK1 cells using 14C palmitic acid as substrate after 1 hr by TLC analysis				Bioorg Med Chem Lett 21: 7205-9 (2011) Article DOI: 10.1016/j.bmcl.2011.09.039 BindingDB Entry DOI: 10.7270/Q2MP53P6
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human))	BDBM50358333 (CHEMBL1922682) Show SMILES FC(F)(F)c1oc(cc1C(=O)Nc1ccc(nc1)N1CCOCC1)-c1ccccc1 Show InChI InChI=1S/C21H18F3N3O3/c22-21(23,24)19-16(12-17(30-19)14-4-2-1-3-5-14)20(28)26-15-6-7-18(25-13-15)27-8-10-29-11-9-27/h1-7,12-13H,8-11H2,(H,26,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human DGAT1 using palmitoyl-1-14C coenzyme A and DAG as substrate after 1 hr by phospholipid flash plate assay				Bioorg Med Chem Lett 21: 7205-9 (2011) Article DOI: 10.1016/j.bmcl.2011.09.039 BindingDB Entry DOI: 10.7270/Q2MP53P6
					More data for this Ligand-Target Pair