BDBM50358338 CHEMBL1922687

SMILES: COCCNc1ccc(NC(=O)c2nc(oc2C(F)(F)F)-c2ccccc2)cn1

InChI Key: InChIKey=ATVVWCUBVDUYSI-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50358338   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human))	BDBM50358338 (CHEMBL1922687) Show SMILES COCCNc1ccc(NC(=O)c2nc(oc2C(F)(F)F)-c2ccccc2)cn1 Show InChI InChI=1S/C19H17F3N4O3/c1-28-10-9-23-14-8-7-13(11-24-14)25-17(27)15-16(19(20,21)22)29-18(26-15)12-5-3-2-4-6-12/h2-8,11H,9-10H2,1H3,(H,23,24)(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.11E+4	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human DGAT1 expressed in CHOK1 cells using 14C palmitic acid as substrate after 1 hr by TLC analysis				Bioorg Med Chem Lett 21: 7205-9 (2011) Article DOI: 10.1016/j.bmcl.2011.09.039 BindingDB Entry DOI: 10.7270/Q2MP53P6
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human))	BDBM50358338 (CHEMBL1922687) Show SMILES COCCNc1ccc(NC(=O)c2nc(oc2C(F)(F)F)-c2ccccc2)cn1 Show InChI InChI=1S/C19H17F3N4O3/c1-28-10-9-23-14-8-7-13(11-24-14)25-17(27)15-16(19(20,21)22)29-18(26-15)12-5-3-2-4-6-12/h2-8,11H,9-10H2,1H3,(H,23,24)(H,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	407	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human DGAT1 using palmitoyl-1-14C coenzyme A and DAG as substrate after 1 hr by phospholipid flash plate assay				Bioorg Med Chem Lett 21: 7205-9 (2011) Article DOI: 10.1016/j.bmcl.2011.09.039 BindingDB Entry DOI: 10.7270/Q2MP53P6
					More data for this Ligand-Target Pair