BDBM50358339 CHEMBL1922688
SMILES: CN(CCO)c1ccc(NC(=O)c2nc(oc2C(F)(F)F)-c2ccccc2)cn1
InChI Key: InChIKey=QRWPZKBCYHRTOL-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human)) | BDBM50358339 (CHEMBL1922688) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 8.09E+3 | n/a | n/a | n/a | n/a |
Roche Research Center Curated by ChEMBL | Assay Description Inhibition of human DGAT1 expressed in CHOK1 cells using 14C palmitic acid as substrate after 1 hr by TLC analysis | Bioorg Med Chem Lett 21: 7205-9 (2011) Article DOI: 10.1016/j.bmcl.2011.09.039 BindingDB Entry DOI: 10.7270/Q2MP53P6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol O-acyltransferase 1 (DGAT1) (Homo sapiens (Human)) | BDBM50358339 (CHEMBL1922688) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 554 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Research Center Curated by ChEMBL | Assay Description Inhibition of human DGAT1 using palmitoyl-1-14C coenzyme A and DAG as substrate after 1 hr by phospholipid flash plate assay | Bioorg Med Chem Lett 21: 7205-9 (2011) Article DOI: 10.1016/j.bmcl.2011.09.039 BindingDB Entry DOI: 10.7270/Q2MP53P6 | |||||||||||
More data for this Ligand-Target Pair |