null

SMILES: COc1cccc(CNC(=O)c2cc3ccc(cc3[nH]2)-c2ccnc(N)n2)c1

InChI Key: InChIKey=LRMGXVOBRWPUFG-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50358471   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM50358471 (CHEMBL1923053) Show SMILES COc1cccc(CNC(=O)c2cc3ccc(cc3[nH]2)-c2ccnc(N)n2)c1 Show InChI InChI=1S/C21H19N5O2/c1-28-16-4-2-3-13(9-16)12-24-20(27)19-11-15-6-5-14(10-18(15)25-19)17-7-8-23-21(22)26-17/h2-11,25H,12H2,1H3,(H,24,27)(H2,22,23,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of ROCK1				Bioorg Med Chem Lett 21: 7107-12 (2011) Article DOI: 10.1016/j.bmcl.2011.09.083 BindingDB Entry DOI: 10.7270/Q20002H5
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50358471 (CHEMBL1923053) Show SMILES COc1cccc(CNC(=O)c2cc3ccc(cc3[nH]2)-c2ccnc(N)n2)c1 Show InChI InChI=1S/C21H19N5O2/c1-28-16-4-2-3-13(9-16)12-24-20(27)19-11-15-6-5-14(10-18(15)25-19)17-7-8-23-21(22)26-17/h2-11,25H,12H2,1H3,(H,24,27)(H2,22,23,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Inhibition of human 6-His-tagged ROCK2 expressed in Sf9 cells				Bioorg Med Chem Lett 21: 7107-12 (2011) Article DOI: 10.1016/j.bmcl.2011.09.083 BindingDB Entry DOI: 10.7270/Q20002H5
					More data for this Ligand-Target Pair