null

SMILES: CCc1ccc(COc2ccc3n(Cc4ccc(cc4)-c4ccc(OC)nc4)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3c2)nc1

InChI Key: InChIKey=VLYGYKJKEWIQAN-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50359063   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM50359063 (CHEMBL1922643) Show SMILES CCc1ccc(COc2ccc3n(Cc4ccc(cc4)-c4ccc(OC)nc4)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3c2)nc1 Show InChI InChI=1S/C38H43N3O4S/c1-8-25-11-15-29(39-21-25)24-45-30-16-17-32-31(19-30)35(46-37(2,3)4)33(20-38(5,6)36(42)43)41(32)23-26-9-12-27(13-10-26)28-14-18-34(44-7)40-22-28/h9-19,21-22H,8,20,23-24H2,1-7H3,(H,42,43)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.39E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amira Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of FLAP in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production preincubated for 5 hrs by ELISA				J Med Chem 54: 8013-29 (2011) Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM50359063 (CHEMBL1922643) Show SMILES CCc1ccc(COc2ccc3n(Cc4ccc(cc4)-c4ccc(OC)nc4)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3c2)nc1 Show InChI InChI=1S/C38H43N3O4S/c1-8-25-11-15-29(39-21-25)24-45-30-16-17-32-31(19-30)35(46-37(2,3)4)33(20-38(5,6)36(42)43)41(32)23-26-9-12-27(13-10-26)28-14-18-34(44-7)40-22-28/h9-19,21-22H,8,20,23-24H2,1-7H3,(H,42,43)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Amira Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]-3-[5-(pyrid-2-ylmethoxy)-3-tert-butylthio-1-benzylindol-2-yl]-2,2-dimethylpropionic acid from FLAP in human polymorphonuclear ce...				J Med Chem 54: 8013-29 (2011) Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM50359063 (CHEMBL1922643) Show SMILES CCc1ccc(COc2ccc3n(Cc4ccc(cc4)-c4ccc(OC)nc4)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3c2)nc1 Show InChI InChI=1S/C38H43N3O4S/c1-8-25-11-15-29(39-21-25)24-45-30-16-17-32-31(19-30)35(46-37(2,3)4)33(20-38(5,6)36(42)43)41(32)23-26-9-12-27(13-10-26)28-14-18-34(44-7)40-22-28/h9-19,21-22H,8,20,23-24H2,1-7H3,(H,42,43)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Amira Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA				J Med Chem 54: 8013-29 (2011) Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM50359063 (CHEMBL1922643) Show SMILES CCc1ccc(COc2ccc3n(Cc4ccc(cc4)-c4ccc(OC)nc4)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3c2)nc1 Show InChI InChI=1S/C38H43N3O4S/c1-8-25-11-15-29(39-21-25)24-45-30-16-17-32-31(19-30)35(46-37(2,3)4)33(20-38(5,6)36(42)43)41(32)23-26-9-12-27(13-10-26)28-14-18-34(44-7)40-22-28/h9-19,21-22H,8,20,23-24H2,1-7H3,(H,42,43)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amira Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of FLAP in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production preincubated for 15 mins by ELISA				J Med Chem 54: 8013-29 (2011) Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W
					More data for this Ligand-Target Pair