null

SMILES: Cc1ccc(COc2ccc3n(Cc4ccc(cc4)-c4cccnc4)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3c2)nc1

InChI Key: InChIKey=NOUDUNZGBPIGQQ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50359085   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM50359085 (CHEMBL1922665) Show SMILES Cc1ccc(COc2ccc3n(Cc4ccc(cc4)-c4cccnc4)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3c2)nc1 Show InChI InChI=1S/C36H39N3O3S/c1-24-9-14-28(38-20-24)23-42-29-15-16-31-30(18-29)33(43-35(2,3)4)32(19-36(5,6)34(40)41)39(31)22-25-10-12-26(13-11-25)27-8-7-17-37-21-27/h7-18,20-21H,19,22-23H2,1-6H3,(H,40,41)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	268	n/a	n/a	n/a	n/a	n/a	n/a
Amira Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of FLAP in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production preincubated for 15 mins by ELISA				J Med Chem 54: 8013-29 (2011) Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM50359085 (CHEMBL1922665) Show SMILES Cc1ccc(COc2ccc3n(Cc4ccc(cc4)-c4cccnc4)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3c2)nc1 Show InChI InChI=1S/C36H39N3O3S/c1-24-9-14-28(38-20-24)23-42-29-15-16-31-30(18-29)33(43-35(2,3)4)32(19-36(5,6)34(40)41)39(31)22-25-10-12-26(13-11-25)27-8-7-17-37-21-27/h7-18,20-21H,19,22-23H2,1-6H3,(H,40,41)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Amira Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]-3-[5-(pyrid-2-ylmethoxy)-3-tert-butylthio-1-benzylindol-2-yl]-2,2-dimethylpropionic acid from FLAP in human polymorphonuclear ce...				J Med Chem 54: 8013-29 (2011) Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM50359085 (CHEMBL1922665) Show SMILES Cc1ccc(COc2ccc3n(Cc4ccc(cc4)-c4cccnc4)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3c2)nc1 Show InChI InChI=1S/C36H39N3O3S/c1-24-9-14-28(38-20-24)23-42-29-15-16-31-30(18-29)33(43-35(2,3)4)32(19-36(5,6)34(40)41)39(31)22-25-10-12-26(13-11-25)27-8-7-17-37-21-27/h7-18,20-21H,19,22-23H2,1-6H3,(H,40,41)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Amira Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]-3-[5-(pyrid-2-ylmethoxy)-3-tert-butylthio-1-benzylindol-2-yl]-2,2-dimethylpropionic acid from FLAP in human polymorphonuclear ce...				J Med Chem 54: 8013-29 (2011) Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W
					More data for this Ligand-Target Pair